Evidence map›Paper›PMID 40767954›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2025

Changes in choroidal vessel morphology associated with fluid leakage in central serous chorioretinopathy; a comparison of OCTA and ICGA.

Payam Kabiri, Steffen Künzel, Shirin Ashraf-Vaghefi, Theresa Bonaventura, Anne Rübsam, Antonia Joussen, Oliver Zeitz

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Payam KabiriDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany. p.kabiri@gmx.de.
Steffen KünzelDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany.
Shirin Ashraf-VaghefiDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany.
Theresa BonaventuraDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany.
Anne RübsamDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany.
Antonia JoussenDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany.
Oliver ZeitzDepartment of Ophthalmology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Hindenburgdamm 30, 12203, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo identify changes in choroidal morphology crucial for CSCR this study assessed the relationship between pachychoroidal changes and the occurrence of CSCR. Additionally, given the undefined role of optical coherence tomography angiography (OCTA) in CSCR diagnosis, this study evaluated OCTA as an alternative to indocyanine green angiography (ICGA).

methodsMultimodal imaging of 99 patients affected by unilateral or bilateral CSCR was retrospectively assessed to identify pachychoroidal changes. Through logistic regression the relationship between these choroidal changes and CSCR occurrence was examined. Evaluation of ICGA and OCTA images was conducted separately, followed by a comparative analysis of the obtained results.

resultsPresence of intervortex venous anastomoses significantly increased the likelihood of CSCR affection (P = 0.0004, odds ratio 4.829), whereas presence of pachyvessels did not (P = 0.7947). Comparative evaluation of pachychoroidal changes between OCTA and ICGA images resulted in 95.16% of cases in coinciding results. OCTA images exhibited less impairment in quality due to subretinal fluid than ICGA images.

conclusionIntervortex venous anastomoses were significantly associated with the presence of subretinal fluid and serous pigment epithelium detachment; however, longitudinal studies are required to establish a causal relationship. OCTA has emerged as a non-invasive alternative to ICGA to assess pachychoroidal changes in patients with CSCR.

Indexed as

Central Serous ChorioretinopathyChoroidFluorescein AngiographyIndocyanine GreenRetinal VesselsSubretinal FluidTomography, Optical CoherenceAdultAgedColoring AgentsFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedColoring AgentsIndocyanine GreenCentral serous chorioretinopathyChoroidal imagingIntervortex venous anastomosesPachychoroidPachyvessels

Identifiers

PMID40767954
PMCPMC12675563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.