ArticleAnnals of surgical oncology2025
Neoadjuvant Treatment and Postoperative Complications After Surgery for Esophageal Cancer: A Population-Based, Nationwide Study in Finland.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Prognostic impact of treatment modalities and examined lymph nodes count on survival in T3-4 esophageal cancer: a retrospective cohort and predictive modeling study from the Surveillance, Epidemiology, and End Results database.Journal of thoracic disease · 2026Article
- Integration of MSK-FI and clinical variables to predict postoperative complications after esophagectomy.Journal of thoracic disease · 2026Article
- Neoadjuvant Therapy for Esophageal Cancer.Cancers · 2026Review
- Association of the preoperative triglyceride-glucose index with postoperative atrial fibrillation following esophagectomy: a retrospective cohort study with a focus on non-diabetic patients.Frontiers in nutrition · 2026Article
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Authors and funding
19 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of neoadjuvant treatment and its modalities in the risk of complications after esophagectomy in national practice is unclear. The aim of this study was to compare postoperative complications after neoadjuvant treatment (nT) and upfront surgery (US), neoadjuvant chemoradiotherapy (nCRT) and neoadjuvant chemotherapy (nCT), and to assess the effect of complications from neoadjuvant treatment in surgical risk. PATIENTS AND
methodsAll patients undergoing esophagectomy for esophageal cancer in Finland in 2005-2016 were included. Incidences of all postoperative complications defined by the Esophagectomy Complications Consensus Group as well as major complications, 90-day mortality, and hospital and ICU stay were reported stratified by treatment strategy (nT versus US, nCRT versus nCT, nT-complication versus no complication). Primary outcomes were compared using logistic regression in these patient groups.
resultsOut of 774 patients, 423 (55%) had nT and 351 (45%) had US. Of the 423 patients undergoing nT, 249 (59%) had nCT, 3 (1%) had radiotherapy only, and 171 (40%) had nCRT. After adjusting for relevant confounders, there were no increases in pneumonia, anastomotic leak, major complications, overall complications, or 90-day mortality with nT compared with US, nCRT compared with nCT, or in patients with nT complications compared with those without.
conclusionsThis nationwide, population-based study reports no difference in postoperative complications or mortality after nT compared with US or nCRT compared with nCT. Patients with neoadjuvant treatment complications were not at higher risk of postoperative complications.
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