Spontaneous Regression of Oral Kaposi Sarcoma in an HIV Negative Male.

Isabella C Galina, Selenne Romero-Servin, Kevin Arce, Angela Rake, Ioannis G Koutlas

Abstract readCase Reports

In one paragraph

Article in Head and neck pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Isabella C GalinaDivision of Oral and Maxillofacial Surgery, School of Dentistry, University of Minnesota, Minneapolis, USA.

Selenne Romero-ServinDivision of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, 515 Delaware Street SE #!6-116B, Minneapolis, MN, 55455, USA.

Kevin ArceDepartment of Oral and Maxillofacial Surgery, Mayo Clinic, Rochester, MN, USA.

Angela RakeDivision of Oral and Maxillofacial Surgery, School of Dentistry, University of Minnesota, Minneapolis, USA.

Ioannis G KoutlasDivision of Oral and Maxillofacial Pathology, School of Dentistry, University of Minnesota, 515 Delaware Street SE #!6-116B, Minneapolis, MN, 55455, USA. koutl001@umn.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral Kaposi sarcoma is a slowly progressing, HHV-8 related angioproliferative disorder strongly associated with immunosuppression. Regression can occur with treatment. We present a 49-year-old HIV-seronegative Caucasian male individual with two rapidly enlarging OKS lesions that spontaneously regressed and completely resolved without treatment after a few months. The individual was under treatment with valacyclovir for herpes simplex infection and was receiving emtricitabine/tenofovir for HIV pre-exposure prophylaxis. Only the mandibular lesion was biopsied, revealing classic endothelial spindle cell proliferation with formation of slit-like spaces and multiple newly formed vessels. Nuclear HHV-8 was immunohistochemically confirmed. Serologic tests prior to and after the development of OKS did not reveal HIV infection. Emtricitabine/tenofovir prophylactic treatment may have contributed to the remission and resolution.

Indexed as

Mouth NeoplasmsNeoplasm Regression, SpontaneousSarcoma, KaposiHerpesvirus 8, HumanHIV SeronegativityHumansMaleMiddle AgedRemission, SpontaneousEmtricitabine/tenofovirHHV8HIVKaposi sarcomaRegression

Identifiers

PMID40767917

DOI10.1007/s12105-025-01832-9

PMCPMC12328849

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.