Evidence map›Paper›PMID 40767883›Full record

ReviewMolecular and cellular biochemistry2025

A review on the epigenetic regulation of testosterone synthesis in Leydig cells.

Haoran Xu, Jing Zhao, Wenfa Lyu, Jun Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Haoran XuKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin Changchun, 130118, China.
Jing ZhaoKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin Changchun, 130118, China.
Wenfa LyuKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin Changchun, 130118, China. wenfa2004@163.com.ORCID http://orcid.org/0000-0002-2417-1096
Jun WangKey Lab of Animal Production, Product Quality and Security, Ministry of Education, Jilin Agricultural University, Jilin Changchun, 130118, China. junwang2004@126.com.ORCID http://orcid.org/0000-0003-2873-384X

Funding

National Natural Science Foundation of China (NSFC) Regional Innovation and Development Joint Fund U22A20509the 14th Five-Year Plan of National Key R&D Program 2021YFF1000701-04
6 · The paper itself

Abstract

Epigenetics studies heritable changes in gene expression without altering the DNA sequence and is involved in diverse biological processes. In male reproduction, Leydig cells, the main site of testosterone synthesis, play an important role in maintaining the reproductive process. However, the role of epigenetics in the mechanism of testosterone synthesis in Leydig cells is still not well understood. This review systematically describes how classic epigenetic modifications such as DNA methylation, RNA methylation, histone modification, and non-coding RNA regulate the testosterone synthesis process of Leydig cells in different species. Accumulating evidences revealed that epigenetics can regulate the process of testosterone synthesis in Leydig cells. In future, we aim to provide new ideas for male reproduction by investigating the relationship between testosterone synthesis mechanisms and epigenetics.

Indexed as

DNA MethylationEpigenesis, GeneticLeydig CellsTestosteroneAnimalsHumansMaleTestosteroneEpigenetic mechanismEpigeneticsLeydig cellsTestosterone synthesis

Identifiers

PMID40767883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.