Evidence map›Paper›PMID 40767842›Full record

ArticleJournal of neurophysiology2025

Early onset of hyperexcitability of medial mammillary body neurons in 5XFAD

Todd L Stincic, Jian Qiu, Cole Martinson, Martin J Kelly, Oline K Ronnekleiv

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid-β Pathology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Todd L StincicDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0001-7504-2422
Jian QiuDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-4988-8587
Cole MartinsonDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0002-8633-2510
Oline K RonnekleivDepartment of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, United States.ORCID 0000-0003-1841-4386

Funding

Sex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1M
Identification of the Neuroprotective STX Receptor in the BrainR21AG080057 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, SCHULTZ, CARSTEN · 2023 to 2024
$424k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01-DK68098NIA NIH HHS R21 AG080057NIDDK NIH HHS R01 DK068098Oregon Health and Science University (OHSU) Circle of Giving
6 · The paper itself

Abstract

There are over seven million people in the United States living with Alzheimer's disease (AD), and two-thirds of these patients are postmenopausal women. In addition to neurodegenerative changes within the cortex and hippocampus, there are pronounced pathological changes in the mammillary bodies (MBs), which are thought to play a role in the development of AD. Currently, we documented in 5XFAD

Indexed as

Alzheimer DiseaseMammillary BodiesNeuronsAction PotentialsAmyloid beta-PeptidesAnimalsDisease Models, AnimalFemaleMaleMiceMice, TransgenicVesicular Glutamate Transport Protein 2Amyloid beta-PeptidesVesicular Glutamate Transport Protein 2mammillary bodypersistent sodium currentT-type calcium currentvesicular glutamate transporter 2β-amyloid

Identifiers

PMID40767842
PMCPMC12453389

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.