Trial reportJournal of the American College of Cardiology2025
Effect of HEPA Filtration Air Purifiers on Blood Pressure: A Pragmatic Randomized Crossover Trial.
Trial report in Journal of the American College of Cardiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Effect of HEPA filtration air purifiers on cognitive function from a secondary outcome analysis of a pragmatic randomized crossover trial.Scientific reports · 2026Trial
- Bedroom Air Filtration and Home Blood Pressures of Older Adults Living in a Residential Facility.Journal of clinical hypertension (Greenwich, Conn.) · 2026Trial
- Health Benefits of Air Purification: A Systematic Review.Environment & health (Washington, D.C.) · 2026Review
- New evidence linking lifestyle factors to blood pressure: Focus on 2024 findings.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Bedroom Air Purification and Home Blood Pressure.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- From Signal to Systems Change: The Convergence of Epidemiology and Implementation Science in Precision Cardiovascular Medicine.Circulation. Population health and outcomes · 2026Article
- Air Pollution and Cardiac Remodeling and Function in Patients With Breast Cancer.JAMA network open · 2026Article
- Effects of Air Pollution on Dialysis and Kidney Transplantation: Clinical and Public Health Action.Journal of clinical medicine · 2025Review
- Breathing Easier: Air Filtration to Improve Indoor Air Quality as a Cardiovascular Intervention.Journal of the American College of Cardiology · 2025Article
- Personal interventions to reduce air pollution exposure in a representative sample of Poles aged 18-64 years.Frontiers in public health · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Funding
Abstract
backgroundParticulate matter (PM) pollution is a leading cause of cardiovascular risk and illness, including elevated blood pressure (BP).
objectivesThe purpose of this study was to test the efficacy of in-home air purifiers to reduce BP for adults living adjacent to highways.
methodsWe conducted a pragmatic randomized crossover trial of the effect of high-efficiency particulate arrestance (HEPA) vs sham filtration on BP. Residences were randomized to start with 1 month of HEPA filtration or 1 month of sham filtration. A 1-month wash out period with no filtration was followed by 1 month of the alternate filtration. Participant questionnaire data and BP were collected 4 times, at the start and end of each filtration period. PM concentrations were measured in a subset of residences. Linear mixed models were used to compare the mean change in BP between the HEPA and sham filtration periods. Models were adjusted for time invariant and time-varying covariates.
resultsA total of 154 participants were analyzed. The mean age was 41.1 years, 59.7% were women, 68.2% were non-Hispanic White, and a majority were of higher socioeconomic status. The mean baseline brachial systolic blood pressure (SBP)/diastolic BP was 118.8/76.5 mm Hg. HEPA filtration significantly reduced PM in comparison to both indoor sham and outdoor levels. Participants' SBP at the start of the intervention period moderated the efficacy of the intervention (P = 0.03). Participants who had elevated brachial SBP (≥120 mm Hg) had a significant 2.8-mm Hg mean reduction in SBP after HEPA filtration (P = 0.03) and a 0.2-mm Hg mean increase in SBP after sham filtration (P = 0.85). The net result was a significant 3.0-mm Hg mean difference in favor of HEPA filtration (P = 0.04). There was no significant benefit on diastolic BP or for participants with normal SBP (<120 mm Hg).
conclusionsThe use of in-home HEPA air purifiers resulted in clinically important reductions in SBP for people with elevated SBP in environments with relatively low PM
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