Evidence map›Paper›PMID 40767639›Full record

ArticleAddiction biology2025

BDNF Haplotype and Personality Traits May Influence the Development of Alcohol Use Disorder in the Han Chinese Population.

Yi-Hsin Wang, Yi-Wei Yeh, Chun-Long Lin, Shin-Chang Kuo, Chun-Yen Chen, Yu-Chieh Huang, Ta-Chuan Yeh, Chih-Yun Huang, Kuo-Hsing Ma, San-Yuan Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yi-Hsin WangDepartment of General Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).ORCID 0009-0000-2683-5717
Yi-Wei YehDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).
Chun-Long LinGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (ROC).
Shin-Chang KuoDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).
Chun-Yen ChenDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).ORCID 0000-0002-8330-9569
Yu-Chieh HuangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).
Ta-Chuan YehDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).
Chih-Yun HuangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).
Kuo-Hsing MaDepartment of Anatomy and Biology, National Defense Medical Center, Taipei, Taiwan (ROC).
San-Yuan HuangDepartment of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (ROC).ORCID 0009-0003-4143-2491

Funding

National Defense Medical Center MND-MAB-D-113105National Defense Medical Center MND-MABD-114126National Science and Technology Council MOST-104-2314-B-016-012-MY3National Science and Technology Council MOST-107-2314-B-016-053-MY2National Science and Technology Council MOST-110-2314-B-016-018-MY2Tri-Service General Hospital TSGH-D-112119Tri-Service General Hospital TSGH-E113288Tri-Service General Hospital TSGH-E-114283
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) and personality traits play a crucial role in the development of alcohol use disorder (AUD). However, the relationship between the BDNF gene, personality and AUD remains unclear. This study aimed to explore the role of BDNF gene variants, personality traits and impulsivity in both the presence of AUD and the age of onset of alcohol dependence. We also examined the interaction between BDNF gene variants and personality traits among individuals with AUD. Eleven polymorphisms encompassing the whole BDNF gene region were genotyped. The Tridimensional Personality Questionnaire (TPQ) and the Barratt Impulsiveness Scale-11 (BIS-11) assessed personality traits and impulsivity. Pearson's Chi-square, HAPLOVIEW software, logistic regression, independent t tests and linear regression were conducted to investigate the associations between BDNF variants, personality traits and impulsivity in patients with AUD. Five-hundred eighty-five AUD patients and 546 normal controls (NC) were recruited for the study. Although no polymorphisms were significantly associated with AUD after Bonferroni correction in gender- or age-stratified analyses, one specific haplotype block (TCA haplotype of rs1519480/rs6265/rs11030101) was related to AUD (p = 6.16 × 10

Indexed as

AlcoholismBrain-Derived Neurotrophic FactorPersonalityAdultAge of OnsetCase-Control StudiesChinaEast Asian PeopleFemaleGenetic Predisposition to DiseaseGenotypeHaplotypesHumansImpulsive BehaviorMaleMiddle AgedBDNF protein, humanBrain-Derived Neurotrophic Factor

Identifiers

PMID40767639
PMCPMC12327066

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.