Evidence map›Paper›PMID 40767554›Full record

ArticlemBio2025

PgtE protease enables virulent

Michael H Lee, Araceli Perez-Lopez, Leigh A Knodler, Grace Nguyen, Gregory T Walker, Judith Behnsen, Steven Silva, Jean Celli, Melissa A Tamin, Michael H Liang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Virulence · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Michael H LeeDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-3676-0306
Araceli Perez-LopezDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Leigh A KnodlerPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-3028-2198
Grace NguyenDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Gregory T WalkerDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Judith BehnsenDepartment of Microbiology and Immunology, University of Illinois Chicago, Chicago, Illinois, USA.ORCID 0000-0003-0109-1090
Steven SilvaDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Jean CelliPaul G. Allen School for Global Health, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA.ORCID 0000-0002-6793-1788
Melissa A TaminDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Michael H LiangDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Karine MelchiorDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Felix A ArguetaDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.
Sean-Paul NuccioDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0002-9683-9278
Manuela RaffatelluDivision of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California, USA.ORCID 0000-0001-6487-4215

Funding

RESEARCH IN INFECTIOUS DISEASEST32AI007036 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR · 1985 to 2025
$9.2M
Training Grant in GastroenterologyT32DK007202 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GHOSH, PRADIPTA · 1985 to 2022
$7.7M
C3-Dependent Intracellular Killing in Innate Immunity and Bacterial PathogenesisR01AI145325 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, RAFFATELLU, MANUELA · 2019 to 2023
$3.1M
Effectors of Brucella intracellular replicationR01AI129992 · NIAID · WASHINGTON STATE UNIVERSITY · PI CELLI, JEAN A · 2017 to 2021
$2.1M
The role of Salmonella protease PgtE in evading host immune responsesF32AI169989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LEE, MICHAEL HWEEMOON · 2022 to 2023
$144k
Burroughs Wellcome Fund G-1019128.01Japan Agency for Medical Research and Development JP233fa627003National Institute of Allergy and Infectious Diseases AI129992National Institute of Allergy and Infectious Diseases AI145325National Institute of Allergy and Infectious Diseases AI169989National Institute of Allergy and Infectious Diseases MISTNational Institute of Allergy and Infectious Diseases T32AI007036NIAID NIH HHS F32 AI169989NIAID NIH HHS R01 AI129992NIAID NIH HHS R01 AI145325NIAID NIH HHS T32 AI007036NIDDK NIH HHS DK007202NIDDK NIH HHS T32 DK007202
6 · The paper itself

Abstract

Non-typhoidal

Indexed as

Bacterial Outer Membrane ProteinsComplement C3Immune EvasionNeutrophilsSalmonella typhimuriumAnimalsHumansMacrophagesMiceSalmonella InfectionsVirulenceBacterial Outer Membrane ProteinsComplement C3bacteremiacomplementmacrophagesneutrophilsproteasesSalmonella

Identifiers

PMID40767554
PMCPMC12345235

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.