ArticleInvestigative ophthalmology & visual science2025
Retinal Neurovascular Signatures in Parkinson's Disease.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Retinal neurovascular signatures in response to 6-month yoga exercise in patients with Parkinson's Disease.Parkinsonism & related disorders · 2026Article
- Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.Translational vision science & technology · 2026Article
- Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults.PloS one · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Purpose: This study aimed to investigate retinal neurovascular signatures in patients with Parkinson's disease (PD) using multimodal neurovascular imaging. Methods: Fifteen patients with clinically diagnosed PD and eighteen age-matched healthy controls (HC) controls were recruited. Retinal blood flow (RBF) was measured using a retinal function imager. Retinal vessel density (RVD), retinal vessel length density (RVLD), and corresponding retinal tissue volume (RTV) were assessed using optical coherence tomography angiography. Retinal tissue perfusion (RTP) was computed as RBF normalized by RTV and retinal capillary function (RCF) as RBF normalized by RVLD. Results: Patients with PD exhibited significantly lower RBF, RTP, and RCF than HC (P < 0.001). RVD, RVLD, and RTV showed no significant difference between groups (P > 0.05). Additionally, the retinovascular variables RBF, RVD, RVLD, and RTV did not share a linear relationship with one another (P > 0.05). Conclusions: To the best of our knowledge, this study is the first to investigate retinal neurovascular signatures and provides novel insights into the interplay between retinal microstructure, microvasculature, and microcirculation in PD. Multimodal retinal imaging may offer a valuable window into the disease mechanism of PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.