Evidence map›Paper›PMID 40767311›Full record

ReviewExperimental physiology2026

Ouabain-induced hypertension in rats: Mechanisms, variability and translational implications.

Priscilla Rodrigues O Feijó, Luis Eduardo M Quintas

Abstract readReview
In one paragraph

Review in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Priscilla Rodrigues O FeijóLaboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-7931-156X
Luis Eduardo M QuintasLaboratório de Farmacologia Bioquímica e Molecular, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0002-0767-1240

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 409436/2016-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 2017/2023Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) 210.309/2019
6 · The paper itself

Abstract

Ouabain-induced hypertension is a multifactorial and condition-dependent phenomenon involving coordinated actions across vascular, renal and central nervous system pathways. At the vascular level, ouabain inhibits Na⁺/K⁺-ATPase, particularly the α2-isoform, leading to elevated intracellular Ca

Indexed as

HypertensionOuabainAnimalsBlood PressureHumansKidneyRatsSodium-Potassium-Exchanging ATPaseOuabainSodium-Potassium-Exchanging ATPasecardiotonic steroidshypertensive rat model

Identifiers

PMID40767311
PMCPMC12949147

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.