ArticleJournal of the American Heart Association2025
Long-Term Outcomes and Predictors in Cancer-Related Stroke Using the Linked Data Set.
Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Stroke secondary to cancer-associated coagulopathy: a systematic review.Journal of neurology · 2026Pooled it
- Predicting cancer aetiology in patients with stroke using brain imaging alone.BMJ neurology open · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData on long-term prognostic factors in patients with cancer-related stroke are limited. The purpose of this study was to evaluate long-term outcomes and investigate prognostic factors of cancer-related stroke using a linked data set.
methodsBetween January 2008 and December 2014, patients with cancer-related stroke (n=690) were included in a linked data set comprising the Health Insurance Review and Assessment Service claims database and the Clinical Research Center for Stroke registry data. Outcomes were long-term mortality, major bleeding including intracerebral hemorrhage and gastrointestinal bleeding, and recurrent ischemic stroke after ischemic stroke. Clinical factors related to outcomes after ischemic stroke, including vascular risk factors, acute stroke management, and types of cancer, were evaluated.
resultsOf the 690 patients with cancer-related stroke (mean age, 68.5 years and 61.7% male) during a median 1.7 year period, 401 (58.1%) patients died during follow-up duration. Multivariate Cox regression analysis revealed that old age (hazard ratio [HR], 1.30 per 10 years [95% CI, 1.17-1.45]), stroke severity (HR, 1.05 [95% CI, 1.03-1.06]), anticoagulation at discharge (HR, 1.67 [95% CI, 1.02-2.74]), and types of cancer, such as pancreatic (HR, 3.73 [95% CI, 2.70-5.16]), hepatobiliary (HR, 2.31 [95% CI, 1.78-3.00]), and lung cancers (HR, 1.73 [95% CI, 1.33-2.25]), were significantly associated with long-term mortality. Major bleeding occurred in 42 patients (6.1%), and recurrent ischemic stroke was observed in 89 patients (12.9%) during the follow-up period.
conclusionLong-term outcomes of cancer-related stroke are poor. Treatment at discharge and cancer type are crucial factors associated with long-term mortality.
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