Evidence map›Paper›PMID 40767285›Full record

ArticleJournal of the American Heart Association2025

Long-Term Outcomes Following Left Atrial Appendage Occlusion in Medicare Beneficiaries: Outcomes From the National Cardiovascular Data Registry.

Angela Y Higgins, Sarah Zimmerman, Yongfei Wang, Daniel J Friedman, Kamil F Faridi, Matthew J Price, Vivek Y Reddy, David R Holmes, Jeptha P Curtis, James V Freeman

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Left Atrial Appendage Occlusion in Cancer-Associated Atrial Fibrillation: Who, When, and How to Manage Antithrombotic Therapy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Angela Y HigginsDepartment of Cardiovascular Medicine Maine Medical Center Portland ME USA.ORCID 0000-0003-3265-5928
Sarah ZimmermanSection of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine New Haven CT USA.ORCID 0000-0003-0219-8498
Yongfei WangSection of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine New Haven CT USA.ORCID 0000-0001-5764-2213
Daniel J FriedmanDivision of Cardiology Duke University Medical Center and Duke Clinical Research Institute Durham NC USA.ORCID 0000-0001-5791-1954
Kamil F FaridiSection of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine New Haven CT USA.ORCID 0000-0002-9276-9110
Matthew J PriceDivision of Cardiovascular Diseases Scripps Clinic La Jolla CA USA.ORCID 0000-0002-7892-2430
Vivek Y ReddyIcahn School of Medicine Mount Sinai New York New York USA.ORCID 0000-0002-5638-4993
David R HolmesDepartment of Cardiovascular Medicine Mayo Clinic Rochester MN USA.ORCID 0000-0002-0037-0373
Jeptha P CurtisSection of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine New Haven CT USA.ORCID 0000-0002-6872-0501
James V FreemanSection of Cardiovascular Medicine, Department of Internal Medicine Yale University School of Medicine New Haven CT USA.ORCID 0000-0002-4614-6879

Funding

Safety and Effectiveness of Left Atrial Appendage Closure in Atrial Fibrillation (SAFELY-AF)R01HL142765 · NHLBI · YALE UNIVERSITY · PI FREEMAN, JAMES · 2019 to 2022
$2.9M
Optimizing Available Data Sources for Post-Marketing Surveillance: Real-World Use of Left Atrial Appendage OcclusionK23HL161424 · NHLBI · YALE UNIVERSITY · PI Kamil Faridi · 2022 to 2026
$950k
NHLBI NIH HHS K23 HL161424NHLBI NIH HHS R01 HL142765
6 · The paper itself

Abstract

backgroundPercutaneous left atrial appendage occlusion (LAAO) is an alternative to long-term anticoagulation for preventing ischemic stroke in patients with atrial fibrillation. There are limited long-term outcomes data for "real-world" patients undergoing LAAO.

methodsWe performed a retrospective cohort study using the National Cardiovascular Data Registry LAAO registry from January 1, 2016, through December 31, 2019. We linked LAAO data to inpatient Medicare fee-for-service claims data using probabilistic matching to establish a cohort of patients 65 years and older undergoing LAAO with a WATCHMAN device. The primary outcomes were any stroke and all-cause mortality.

resultsA total of 34 975 patients with a mean±SD CHA

conclusionsLong-term stroke rates in a large nationally representative cohort of Medicare patients following LAAO were low and durably consistent during long-term follow-up despite a high thromboembolic risk. High mortality rates in this elderly population underscore the importance of incorporating patient values and preferences when considering LAAO.

Indexed as

Atrial AppendageAtrial FibrillationIschemic StrokeMedicareStrokeAgedAged, 80 and overFemaleHumansIncidenceMaleRegistriesRetrospective StudiesRisk FactorsTime FactorsTreatment Outcomeleft atrial appendage occlusionmortalityoutcomesstroke

Identifiers

PMID40767285
PMCPMC12533740

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.