Evidence map›Paper›PMID 40767160›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Crown Ether-Peptide Rotaxanes.

Peng-Lai Wang, Peng Chen, Raorao Yang, Daniel J Tetlow, Zhi-Hui Zhang, Jing Han, Stephen D P Fielden, Prodip Howlader, Liang Zhang, David A Leigh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026
    Review
  4. Article
  5. Article
  6. Crown Ether-Peptide Rotaxanes.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peng-Lai Wang *School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.ORCID https://orcid.org/0000-0002-2295-0096
Peng Chen *School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.
Raorao YangSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.
Daniel J TetlowDepartment of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.ORCID https://orcid.org/0000-0001-6323-3483
Zhi-Hui ZhangSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.ORCID https://orcid.org/0000-0001-8927-1154
Jing HanSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.
Stephen D P FieldenDepartment of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.ORCID https://orcid.org/0000-0001-7883-8135
Prodip HowladerDepartment of Chemistry, University of Manchester, Oxford Road, Manchester, M13 9PL, UK.ORCID https://orcid.org/0000-0001-6762-529X
Liang ZhangSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.ORCID https://orcid.org/0009-0009-6035-6774
David A LeighSchool of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200062, P.R. China.ORCID https://orcid.org/0000-0002-1202-4507

Funding

China Scholarship Council 202108310032Engineering and Physical Sciences Research Council EP/P027067/1European Research Council 786630
6 · The paper itself

Abstract

We report on the metal-free active template synthesis of crown ether-peptide rotaxanes. A 24-crown-8 ring is sufficiently small that the side chains of canonical branched amino acids act as barriers that trap the macrocycle on the particular glycine residue used to assemble the rotaxane. The resulting crown ether-tripeptide rotaxane can subsequently be extended from either or both N- and C-termini of the axle. Three distinct positional isomers of a heptapeptide [2]rotaxane containing three glycine units were selectively synthesized, and in each case the unique position of the crown ether on the peptide axle was confirmed by

Indexed as

Active template synthesisLasso peptidesMechanically interlocked moleculesRotaxanes

Identifiers

PMID40767160
PMCPMC12435445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.