Identifying Modulators of the Post-Antibiotic Effect.
Alexa L Gilberti, Megan M Tu, Kenneth Rachwalski, Madeeha I Ali, Siobhan A Cohen, Melike Akoglu, Alyssa C Pollard-Kerning, Jinnette Tolentino Collado, Aya Sabbah, Franchesca Abou Said and 5 more
Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jinnette Tolentino ColladoChemistry Department, Farmingdale State College, Farmingdale, New York 11735, United States.
Aya Sabbah
Franchesca Abou Said
Purnima Dela
Stephen G WalkerDepartment of Oral Biology and Pathology, Stony Brook University, Stony Brook, New York 11794-8702, United States.
John D HaleyDepartment of Pathology, Stony Brook University, Stony Brook, New York 11794-8691, United States.
Eric D BrownInstitute of Infectious Disease Research, McMaster University, Hamilton, Ontario L8S 4L8, Canada.ORCID 0000-0002-7624-8112
Peter J TongeDepartment of Biomedical Genetics, University of Rochester, Rochester, New York 14642-2630, United States.ORCID 0000-0003-1606-3471
Funding
IRACDA - The New York Consortium for the Advancement of Postdoctoral Scholars (NY CAPS)Phase IIK12GM102778 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Carol A. Carter, Karian Janice Wright · 2012 to 2026
$13.1M
Chemical Biology Training InterfaceT32GM136572 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI ELIZABETH M BOON, Jessica Chuang Seeliger · 2020 to 2026
$2.9M
IMSD at Stony Brook University: Maximizing Excellence in Research for Graduate Education -- Fostering Inclusive Research Scientist Training (FIRST)T32GM135746 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI GERGEN, JOHN PETER · 2021 to 2025
$2.3M
SBU Chemistry-Biology Interface Training ProgramT32GM092714 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI SAMPSON, NICOLE S, TONGE, PETER J · 2010 to 2019
$1.7M
Mechanism of Slow Onset Enzyme Inhibition and Translation to Time-Dependent Drug ActivityR35GM149297 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI PETER J TONGE · 2023 to 2026
$1.6M
Scholars in BioMedical Sciences (SBMS) Training ProgramT32GM127253 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI TSIRKA, STYLIANI-ANNA (STELLA) E · 2018 to 2022
The postantibiotic effect (PAE) is the delay in bacterial regrowth following antibiotic removal. It has important implications for dosing regimens since drugs that have extended activity following their elimination can be dosed less frequently, widening the therapeutic window. While the PAE has been associated with target vulnerability and the rate of target turnover, little is known about the genetic components that modulate the PAE. Here, we developed a high-throughput assay to screen the
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Identifying Modulators of the Post-Antibiotic Effect. · full record | OpenQuestion