SynthesisFrontiers in pediatrics2025
Non-contrast enhanced functional lung MRI in children: systematic review.
Synthesis in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Adapted Linear Binning Method to Assess Pulmonary Ventilation and Perfusion in Children Using Lung Matrix Pencil Decomposition (MP)-MRI.Magnetic resonance in medicine · 2026Article
- Accelerating PREFUL MRI: Comparison of Registration Methods and Impact of Time Series Reduction.NMR in biomedicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Magnetic resonance imaging (MRI) of the lung is well suited for repeated measurements especially in children due to the absence of ionizing radiation. Furthermore, non-contrast-enhanced (NCE) functional MRI techniques provide localized functional information on ventilation and perfusion without specialized set-ups (e.g., hyperpolarized gases) using standard clinical MRI systems. Current NCE-MRI techniques in the pediatric setting are matrix-pencil decomposition (MP)-MRI, phase-resolved functional lung (PREFUL)-MRI, self-gated non-contrast-enhanced functional lung (SENCEFUL)-MRI and Fourier decomposition (FD)-MRI. In this article, we comprehensively discuss these innovative techniques. Study design: We review relevant functional NCE-MRI techniques based on a systematic literature research in MEDLINE, Embase, Cochrane Library, ClinicalTrials.gov and ICTRP. Core concepts were: 1. Aspects regarding lungs 2. MP-, PREFUL-, SENCEFUL and FD-MRI, and 3. children. Consecutively, we included 30 reports. Results: Functional NCE-MRI in the pediatric setting has been successfully validated and used in observational studies covering a great variety of lung diseases. In contrast to initial implementation studies additionally reporting on clinical findings, later studies focus primarily on clinical topics. Heterogeneous study designs and examination protocols hamper the direct comparability between the different NCE-MRI techniques in terms of their performance against current functional imaging standards or specific objectives. Conclusion: Their easy applicability makes NCE-MRI techniques highly attractive for widespread clinical use. Following successful implementation studies, still varying test protocols and approaches for calculating outcome values must next be compared and standardized.
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Registered trials
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