ArticleApplications in plant sciences
A new spin on chemotaxonomy: Using non-proteogenic amino acids as a test case.
Article in Applications in plant sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Structurally diverse acylsugars on wild tomatillo fruit surfaces.Horticulture research · 2026Article
- Evidence that non-cognate proteinogenic amino acids generate immunogenic neoepitopes.The Journal of biological chemistry · 2026Review
- A new spin on chemotaxonomy: Using non-proteogenic amino acids as a test case.Applications in plant sciencesArticle
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Authors and funding
5 authors.
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Abstract
Premise: Specialized metabolites serve various roles for plants and humans. Unlike core metabolites, specialized metabolites are restricted to certain plant lineages; thus, in addition to their ecological functions, specialized metabolites can serve as diagnostic markers of plant lineages. Methods: We investigated the phylogenetic distribution of plant metabolites using non-proteogenic amino acids (NPAA). Species-NPAA associations for eight NPAAs were identified from the existing literature and placed within a phylogenetic context using R packages and the Interactive Tree of Life. To confirm and extend the literature-based NPAA distribution, we selected azetidine-2-carboxylic acid (Aze) and screened over 70 diverse plants using gas chromatography-mass spectrometry (GC-MS). Results: Literature searches identified 163 NPAA-relevant articles, which were manually inspected to identify 822 species-NPAA associations. NPAAs were mapped at the order and genus level, revealing that some NPAAs are restricted to single orders, whereas others are present across divergent taxa. The observed distribution of Aze across plants and ancestral state reconstruction suggests a convergent evolutionary history. Discussion: Although reliance on chemotaxonomy has decreased in recent years, there is still value in placing metabolites within a phylogenetic context to understand the evolutionary processes of plant chemical diversification. This approach can be applied to metabolites present in any organism and compared at a range of taxonomic levels.
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