Evidence map›Paper›PMID 40766811›Full record

ArticleBlood vessels, thrombosis & hemostasis2024

Clusterin can mediate apoptosis-induced molecular mechanisms in immune thrombocytopenia.

Tea Stein, Christina Bitsina, Michelle Seiler, Markus Schmugge, Francesca D Franzoso

Abstract read
In one paragraph

Article in Blood vessels, thrombosis & hemostasis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tea SteinDivision of Hematology, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Christina BitsinaDivision of Hematology, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Michelle SeilerEmergency Department, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Markus SchmuggeDivision of Hematology, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.
Francesca D FranzosoDivision of Hematology, Children's Research Center, University Children's Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormalities in the apoptosis pathway have been implicated into the pathogenesis of various autoimmune diseases, including immune thrombocytopenia (ITP). Our data suggest that mechanisms associated with impaired clusterin-mediated apoptosis might play a role in the pathophysiology of ITP platelets and their production by MKs. Platelet-rich plasma from 10 patients with ITP compared with healthy controls was used for the apoptosis proteomic profiling and clusterin (

Identifiers

PMID40766811
PMCPMC12320419

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.