Evidence map›Paper›PMID 40766807›Full record

ArticleJournal of experimental orthopaedics2025

Creation and validation of a treatment algorithm for skeletally immature patients with acute anterior cruciate ligament injury based on MRI and patient characteristics.

Alberto Grassi, Kyle Borque, Martijn Dietvorst, Emanuele Altovino, Claudio Rossi, Luca Ambrosini, Alice Bondi, Stefano Zaffagnini

Abstract read
In one paragraph

Article in Journal of experimental orthopaedics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Pediatric ACL Injuries: A Current Concepts Review.Journal of clinical medicine · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alberto GrassiDipartimento di Scienze Biomediche e Neuromotorie DIBINEM Università di Bologna Bologna Italy.ORCID https://orcid.org/0000-0003-4236-1798
Kyle BorqueHouston Methodist Hospital Houston Texas USA.ORCID https://orcid.org/0000-0001-5543-2124
Martijn DietvorstMáxima MC Eindhoven the Netherlands.ORCID https://orcid.org/0000-0003-3581-287X
Emanuele AltovinoClinica Ortopedica e Traumatologica II, Istituto Ortopedico Rizzoli Bologna Italy.ORCID https://orcid.org/0009-0004-5480-6138
Claudio RossiClinica Ortopedica e Traumatologica II, Istituto Ortopedico Rizzoli Bologna Italy.ORCID https://orcid.org/0009-0003-3808-9733
Luca AmbrosiniClinica Ortopedica e Traumatologica II, Istituto Ortopedico Rizzoli Bologna Italy.ORCID https://orcid.org/0000-0003-2811-6817
Alice BondiDipartimento Rizzoli Sicilia, Istituto Ortopedico Rizzoli Bagheria Palermo Italy.
Stefano ZaffagniniDipartimento di Scienze Biomediche e Neuromotorie DIBINEM Università di Bologna Bologna Italy.ORCID https://orcid.org/0000-0002-2941-1407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study aimed to develop and validate a clinical decision-making algorithm, the 'Best ACL-treatment Based on the Years of the Knee' (BABY-Knee) Algorithm, for treating acute anterior cruciate ligament (ACL) injuries in skeletally immature patients. The algorithm integrates magnetic resonance imaging (MRI) findings and patient-specific characteristics to differentiate cases suitable for conservative management from those requiring surgical intervention. Methods: A prospective cohort of 75 skeletally immature patients (mean age: 13.9 ± 2.2 years) diagnosed with ACL rupture at a single institution between February 2022 and October 2024 was evaluated. Patients were categorized as surgical or non-surgical candidates based on the BABY-Knee Algorithm, which incorporates six weighted criteria: MRI-detected meniscal tears, lateral tibiofemoral bone bruises, skeletal age, injury mechanism and rotatory laxity. Outcomes of initial management were retrospectively analyzed for algorithm validation. Results: Of the 75 patients, 55 (73.3%) underwent surgical reconstruction, while 20 (26.7%) were managed conservatively. Conservative treatment failed in 12 cases (60%), necessitating surgical intervention. Retrospective application of the algorithm yielded a positive predictive value of 91.7% for identifying surgical candidates and a negative predictive value of 87.5% for successful conservative treatment. Conclusion: The BABY-Knee Algorithm demonstrated high reliability in guiding treatment decisions for skeletally immature patients with acute ACL injuries, predicting outcomes of conservative treatment in nearly 90% of cases. Further studies are required to confirm its applicability in additional prospective case series. Level of Evidence: Level IV, case series.

Indexed as

ACLalgorithmMRIpaediatricphyseal sparingskeletally immature

Identifiers

PMID40766807
PMCPMC12322690

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.