ArticleFrontiers in pharmacology2025
Clinical manifestations, diagnostic criteria, and treatment outcomes of minocycline-associated DRESS syndrome: a comprehensive exploration of published cases.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Minocycline-induced DRESS: could dosage in relation to body fat mass be a contributing factor?Frontiers in pharmacology · 2025Article
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2 authors.
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Abstract
Introduction: Minocycline can induce a rare but serious adverse drug reaction known as drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. We explored the clinical features of minocycline-associated DRESS to aid in early diagnosis and risk mitigation. Methods: A comprehensive exploration of published cases from the start of electronic databases (PubMed, Embase, Web of Science, CNKI, Wanfang Data) to December 1, 2024. Cases were screened using RegiSCAR criteria. Results: A total of 3,928 citations were identified through database searches, and after screening, 39 case reports (comprising 57 patients) were included. Fifty-seven patients (mean age 37.1 years) exhibited median DRESS onset at 17.5 days. Respiratory symptoms (87.7%, n = 50) dominated, including non-productive cough, dyspnea, pharyngitis, and wheezing. Fever occurred in 45 (78.9%) patients. Median eosinophilia peaked at 4.09 × 10 Conclusion: Minocycline-associated DRESS syndrome is characterized by diverse clinical manifestations, including prominent respiratory symptoms. Timely drug cessation, corticosteroid therapy, and vigilant monitoring are critical to optimize outcomes. These findings underscore the need for enhanced pharmacovigilance in high-risk populations.
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