Evidence map›Paper›PMID 40766755›Full record

ArticleFrontiers in pharmacology2025

Oluwafemi Ezekiel Kale, Sheng Hu, Claudia Huber, Felix Schierholz, Anna Ciotkowska, Alexander Tamalunas, Christian G Stief, Wolfgang Eisenreich, Martin Hennenberg

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A Bioactive Benzyl Terpene fromMolecules (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Oluwafemi Ezekiel KaleDepartment of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, Ago-Iwoye, Sagamu Campus, Olabisi Onabanjo University, Ago Iwoye, Nigeria.
Sheng HuDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Claudia HuberBavarian NMR Center - Structural Membrane Biochemistry, Department of Chemistry, Technical University of Munich, Munchen, Germany.
Felix SchierholzDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Anna CiotkowskaDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Alexander TamalunasDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Christian G StiefDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.
Wolfgang EisenreichBavarian NMR Center - Structural Membrane Biochemistry, Department of Chemistry, Technical University of Munich, Munchen, Germany.
Martin HennenbergDepartment of Urology, LMU University Hospital, LMU Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The limited tolerability and efficacy of synthetic drugs have hindered the effective management of lower urinary tract symptoms (LUTSs). In African traditional medicine, species of the genus Methods: Cumulative concentration-response curves were generated for both adrenergic and cholinergic agonists, and electrical field stimulation (EFS) in organ bath experiments. In addition, assays were conducted to evaluate cell proliferation and viability, providing complementary insights into functional and cellular-level effects. The bioactive compounds in the extract were characterized using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy and were subsequently evaluated Results: Prostate tissue contractions induced by α Conclusion: In this study, we report for the first time that

Indexed as

Acridocarpus smeathmannii root extractlower urinary tract symptomsphytomedicineporcine arteriessmooth muscle contraction

Identifiers

PMID40766755
PMCPMC12321789

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.