ArticlebioRxiv : the preprint server for biology2025
Comprehensive Transcriptomic and Epigenomic Insights into Environmental Toxicant Exposures: The TaRGET II Resource.
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In one paragraph
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Corrections and comments
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Authors and funding
32 authors.
Bo A ZhangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.ORCID 0000-0003-2962-5314
Benpeng MiaoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Shuhua FuDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Cristian CoarfaDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Ravindra KumarDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Prashant Kumar KuntalaDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Bongsoo ParkDepartment of Environmental Health and Engineering, School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Sandra L GrimmDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Rahul JangidDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Justin A ColacinoDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109 USA.
Laurie K SvobodaDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109 USA.
Wanqing ShaoDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Xiaoyun XingDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Daofeng LiDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Shaopeng LiuDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.
Robert B HamanakaDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, USA.
Claudia LalancetteEpigenomics Core, University of Michigan, Ann Arbor, MI 48109 USA.
Maureen A SartorDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109 USA.
Christopher KrappDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Gregory E CrawfordDivision of Medical Genetics, Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA.
Heather B PatisaulDepartment of Biological Sciences, North Carolina State University, Raleigh, NC 27695.
Tim WiltshireEshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC.
TaRGET II Consortium
David AylorDepartment of Biological Sciences, North Carolina State University, Raleigh, NC 27695.
Shyam BiswalDepartment of Environmental Health and Engineering, School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Gökhan M MutluDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, IL 60637, USA.
Sanjay RajagopalanCardiovascular Research Institute, School of Medicine, Case Western Reserve University, OH 44106, USA.
Wan-Yee TangDepartment of Environmental and Occupational Health, University of Pittsburgh School of Public Health, Pittsburgh, PA 15216, USA.
Ting WangDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Dana C DolinoyDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109 USA.
Marisa S BartolomeiDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9410-5222
Cheryl WalkerDan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3MThe WashU-UCSC-EBI Human Genome Reference Center."U41HG010972 · NHGRI · WASHINGTON UNIVERSITY · PI Ira M Hall, Heng Li · 2019 to 2026
$24.9MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Cheryl L. Walker · 2019 to 2026
$14.7MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MWashU-Northwestern Genomic Variation and Function Data and Administrative Coordinating CenterU24HG012070 · NHGRI · WASHINGTON UNIVERSITY · PI Ting Wang, Feng Yue · 2021 to 2026
$9.7MEnvironmental Epigenomics and Precision Environmental HealthR35ES031686 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2020 to 2026
$6.1MTHE WASHU TARGET ENVIRONMENTAL EPIGENOMICS DATA COORDINATION CENTERU24ES026699 · NIEHS · WASHINGTON UNIVERSITY · PI WANG, TING · 2016 to 2021
$5.2MWashU Somatic Mosaicism across Human Tissues (SMaHT) Program Organizational CenterU24NS132103 · NINDS · WASHINGTON UNIVERSITY · PI FULTON, LUCINDA, LAWSON, HEATHER A. · 2023 to 2025
$4.5MPerinatal Exposures, Tissue- and Cell-specific Epigenomics, & Lifecourse OutcomesU01ES026697 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DOLINOY, DANA · 2016 to 2019
$3.6MEpigenetic Signatures of Developmental Reprogramming in Target and Surrogate TissuesU01ES026719 · NIEHS · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI BARTOLOMEI, MARISA S., WALKER, CHERYL L. · 2016 to 2020
$3.4MSystems Toxicogenomics of Endocrine Disrupting Chemicals in BrainU01ES026717 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI AYLOR, DAVID LAWRENCE · 2016 to 2019
$2.9MNHGRI NIH HHS U24 HG012070NHGRI NIH HHS U41 HG010972NIEHS NIH HHS P30 ES013508NIEHS NIH HHS P30 ES017885NIEHS NIH HHS P30 ES027792NIEHS NIH HHS P30 ES030285NIEHS NIH HHS R35 ES031686NIEHS NIH HHS RC2 ES018789NIEHS NIH HHS U01 ES026697NIEHS NIH HHS U01 ES026717NIEHS NIH HHS U01 ES026718NIEHS NIH HHS U01 ES026719NIEHS NIH HHS U24 ES026699NIGMS NIH HHS R35 GM142917NINDS NIH HHS U24 NS132103
Abstract
Environmental exposures to toxic chemicals can profoundly alter the transcriptome and epigenome in both humans and animals, contributing to disease development across the lifespan. To elucidate how early-life exposure to toxicants exerts such persistent effects, the
Indexed as
arsenic (As)bisphenol a (BPA)chromatinDevelopmental Origins of Disease (DOHaD)dioxin (TCDD)DNA methylationgene expressionHistone modificationslead (Pb)particulate matter (PM2.5)phthalates (DEHP)Toxicoepigeneticstributyltin (TBT)
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.