Evidence map›Paper›PMID 40766674›Full record

ArticlebioRxiv : the preprint server for biology2025

A lncRNA drives developmentally-timed decay of all members of an essential microRNA family.

Acadia L Grimme, Lu Li, Alyshia Scholl, Bridget F Donnelly, Neha Channamraju, Karl-Frédéric Vieux, Lecong Zhou, Geraldine Seydoux, Mingyi Xie, Katherine McJunkin

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Acadia L GrimmeNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, MD.
Lu LiUniversity of Florida, Department of Biochemistry, Gainesville, FL.
Alyshia SchollJohns Hopkins School of Medicine, Department of Molecular Biology and Genetics, Baltimore, MD.ORCID 0000-0001-5355-9383
Bridget F DonnellyNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, MD.
Neha ChannamrajuNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, MD.
Karl-Frédéric VieuxNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, MD.
Lecong ZhouNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, MD.
Geraldine SeydouxJohns Hopkins School of Medicine, Department of Molecular Biology and Genetics, Baltimore, MD.ORCID 0000-0001-8257-0493
Mingyi XieUniversity of Florida, Department of Biochemistry, Gainesville, FL.ORCID 0000-0001-7955-197X
Katherine McJunkinNational Institute of Diabetes and Digestive and Kidney Diseases Intramural Research Program, Bethesda, MD.ORCID 0000-0001-9730-442X

Funding

Biological functions and post-transcriptional regulation of microRNAsZIADK075147 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI MCJUNKIN, KATHERINE · 2018 to 2025
$14.4M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Intramural NIH HHS ZIA DK075147NIH HHS P40 OD010440
6 · The paper itself

Abstract

The spatiotemporal expression patterns of microRNAs (miRNAs) are crucial to their function. Target-directed miRNA degradation (TDMD) is an emerging regulatory module that contributes to these expression patterns wherein a specialized RNA (TDMD trigger) drives miRNA decay through base pairing and resulting recruitment of E3 ubiquitin ligase ZSWIM8/EBAX-1. Extensive base pairing to the miRNA seed region and 3' end has been proposed as a key feature that distinguishes TDMD triggers from conventional mRNA targets of miRNAs, which primarily pair with the seed. Here we identify the long noncoding RNA,

Indexed as

AgoArgonauteEBAX-1mir-35 familymiRISCRISCZSWIM8

Identifiers

PMID40766674
PMCPMC12324485

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.