Evidence map›Paper›PMID 40766670›Full record

ArticlebioRxiv : the preprint server for biology2025

Altered striatal dopamine regulation in

Nicole A Perry-Hauser, Arturo Torres-Herraez, Siham Boumhaouad, Emily A Makowicz, Daniel C Lowes, Michelle Jin, Christine A Denny, David Sulzer, Eugene V Mosharov, Christoph Kellendonk and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Nicole A Perry-HauserDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.ORCID 0000-0003-3130-3023
Arturo Torres-HerraezDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Siham BoumhaouadDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Emily A MakowiczDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Daniel C LowesDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Michelle JinDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Christine A DennyDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
David SulzerDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Eugene V MosharovDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Christoph KellendonkDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.
Jonathan A JavitchDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY 10032, USA.

Funding

Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
Research Training in Mood and Anxiety Disorders: From Animal Models to PatientsT32MH015144 · NIMH · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Eduardo David Leonardo · 1985 to 2026
$11.1M
The Dopamine Synapse and Associative LearningR01DA007418 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David Sulzer · 1999 to 2026
$9.4M
Co-Regulation of Striatal Dopamine and Acetylcholine During Flexible LearningR01MH124858 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI KELLENDONK, CHRISTOPH · 2021 to 2025
$2.7M
NIDA NIH HHS R01 DA007418NIMH NIH HHS R01 MH054137NIMH NIH HHS R01 MH124858NIMH NIH HHS T32 MH015144
6 · The paper itself

Abstract

Dopaminergic signaling is essential for regulating movement, learning, and reward. Disruptions in this system are linked to neuropsychiatric disorders such as ADHD. ADGRL3, an adhesion G protein-coupled receptor highly expressed in the brain, is genetically associated with increased ADHD risk.

Identifiers

PMID40766670
PMCPMC12324523

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.