ArticlebioRxiv : the preprint server for biology2025
Origin and novel transport pathways of bacterial hopanoids.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Hopanoids are bacterial lipids that fortify membranes and enhance stress resistance. Derivatives of hopanoids known as "geo-hopanes" are abundant signatures of ancient bacteria in sediments, yet there are conflicting views on whether they are markers of specific taxa or environments. Here we analyze conservation of hopanoid biosynthesis across bacterial genomes using modern taxonomic tools. We find that hopanoids most likely originated in an ancestor of the pseudomonadota, and that tolerance of high osmolarity is the most common feature of hopanoid-producing strains. Additionally, microsynteny with hopanoid-related loci revealed new hopanoid-associated gene families, which we term
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