Evidence map›Paper›PMID 40766664›Full record

ArticlebioRxiv : the preprint server for biology2025

Aggressive Cholesterol Lowering Normalizes Atherosclerosis Regression in

Brian D Hardaway, Trevor P Fidler, Mojdeh Tavallaie, Kleopatra Avrampou, Cheng-Chieh Hsu, Sandra Schiavone, Tong Xiao, Nan Wang, Alan R Tall

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Brian D HardawayDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0003-0622-3494
Trevor P FidlerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-0758-9984
Mojdeh TavallaieDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-7166-2499
Kleopatra AvrampouDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0009-0008-4422-5064
Cheng-Chieh HsuDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-3423-7159
Sandra SchiavoneDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Tong XiaoDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Nan WangDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.
Alan R TallDivision of Molecular Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-7708-2417

Funding

Tumor Biology and Microenvironment ProgramP30CA013696 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Anil K Rustgi · 1985 to 2026
$115.3M
Mouse and Human Atherosclerotic TissueP01HL172741 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hanrui Zhang · 2024 to 2026
$9.5M
JAK2V617F, clonal hematopoiesis and atherosclerosisR01HL148071 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NAN WANG · 2019 to 2026
$4.0M
Clonal hematopoiesis, inflammasomes and atherosclerosisR01HL155431 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALAN richard TALL · 2021 to 2026
$3.7M
New therapeutic approaches in clonal hematopoiesis and atherosclerosisR01HL170157 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI TALL, ALAN RICHARD · 2023 to 2023
$695k
NCI NIH HHS P30 CA013696NHLBI NIH HHS P01 HL172741NHLBI NIH HHS R01 HL148071NHLBI NIH HHS R01 HL155431NHLBI NIH HHS R01 HL170157
6 · The paper itself

Abstract

Background –: The Methods and Results –: Chimeric Conclusions –: Aggressive LDL lowering reverses inflammasome activation and induces pro-resolving changes in macrophages in

Indexed as

absent in melanoma 2atherosclerotic plaque regressionbone marrowclonal hematopoiesisfoam cellsinflammasomeinflammationJak2V617F mutationLDLvascular biology

Identifiers

PMID40766664
PMCPMC12324260

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.