Evidence map›Paper›PMID 40766663›Full record

ArticlebioRxiv : the preprint server for biology2025

NAC controls nascent chain fate through tunnel sensing and chaperone action.

Jae Ho Lee, Laurenz Rabl, Martin Gamerdinger, Vaishali Goyal, Katrin Michaela Khakzar, Natalia Moreira Barbosa, Juliana Abramovich, Fabian Morales-Polanco, Ann-Kathrin Köhler, Ekaterina Samatova and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jae Ho LeeDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-8663-3209
Laurenz RablDepartment of Biology, Molecular Microbiology, University of Konstanz, 78457 Konstanz, Germany.
Martin GamerdingerDepartment of Biology, Molecular Microbiology, University of Konstanz, 78457 Konstanz, Germany.
Vaishali GoyalDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Goettingen 37077, Germany.
Katrin Michaela KhakzarDepartment of Biology, Molecular Microbiology, University of Konstanz, 78457 Konstanz, Germany.
Natalia Moreira BarbosaDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Juliana AbramovichDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Fabian Morales-PolancoDepartment of Biology, Stanford University, Stanford, CA 94305, USA.
Ann-Kathrin KöhlerDepartment of Biology, Molecular Microbiology, University of Konstanz, 78457 Konstanz, Germany.
Ekaterina SamatovaDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Goettingen 37077, Germany.
Marina V RodninaDepartment of Physical Biochemistry, Max Planck Institute for Multidisciplinary Sciences, Goettingen 37077, Germany.
Elke DeuerlingDepartment of Biology, Molecular Microbiology, University of Konstanz, 78457 Konstanz, Germany.
Judith FrydmanDepartment of Biology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-2302-6943

Funding

The proteasome in aging and neurodegenerative diseaseP01AG054407 · NIA · NORTHWESTERN UNIVERSITY · PI FINLEY, DANIEL J · 2018 to 2022
$14.0M
Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
PROTEIN FOLDING IN THE EUKARYOTIC CYTOSOLR01GM056433 · NIGMS · STANFORD UNIVERSITY · PI Judith Frydman · 1997 to 2026
$5.0M
NIA NIH HHS P01 AG054407NIA NIH HHS T32 AG000266NIGMS NIH HHS R01 GM056433
6 · The paper itself

Abstract

The nascent polypeptide-associated complex (NAC) is a conserved ribosome-bound factor with essential yet incompletely understood roles in protein biogenesis. Here, we show that NAC is a multifaceted regulator that coordinates translation elongation, cotranslational folding, and organelle targeting through distinct interactions with nascent polypeptides both inside and outside the ribosome exit tunnel. Using NAC-selective ribosome profiling in

Identifiers

PMID40766663
PMCPMC12324276

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.