Evidence map›Paper›PMID 40766652›Full record

ArticlebioRxiv : the preprint server for biology2025

Regulatory T cells epigenetically reprogrammed from autoreactive effector T cells mitigate established autoimmunity.

Tyler R Colson, James J Cameron, Hayley I Muendlein, Mei-An Nolan, Jamie L Leiriao, James H Kim, Alexander N Poltorak, Xudong Li

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Tyler R ColsonGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.ORCID 0000-0001-7124-2208
James J CameronGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Hayley I MuendleinDepartment of Immunology, Tufts University School of Medicine; Boston, MA, 02111, USA.
Mei-An NolanGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Jamie L LeiriaoGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
James H KimDepartment of Immunology, Tufts University School of Medicine; Boston, MA, 02111, USA.
Alexander N PoltorakGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.
Xudong LiGraduate Program in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA 02111, USA.

Funding

Regulation of LPS-responses by ZBP1R01AI167245 · NIAID · TUFTS UNIVERSITY BOSTON · PI POLTORAK, ALEXANDER · 2021 to 2025
$3.6M
Spectral Cell SorterS10OD032201 · OD · TUFTS UNIVERSITY BOSTON · PI TAI, ALBERT K · 2022 to 2022
$672k
BD Influx 5 Laser Fluorescence Activated Cell SorterS10OD016196 · OD · TUFTS UNIVERSITY BOSTON · PI THORLEY-LAWSON, DAVID A. · 2013 to 2013
$600k
NIAID NIH HHS R01 AI167245NIH HHS S10 OD016196NIH HHS S10 OD032201
6 · The paper itself

Abstract

Reprogramming autoreactive CD4

Identifiers

PMID40766652
PMCPMC12324233

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.