Evidence map›Paper›PMID 40766650›Full record

ArticlebioRxiv : the preprint server for biology2025

NLRP3 inflammasome is regulated in osteoclasts through a Tmem178-dependent mechanism that restricts calcium influx.

Khushpreet Kaur, Yael Alippe, Chun Wang, Nicholas P Semenkovich, Saumya Bhagat, Kunjan Khanna, Yongjia Li, Nitin Pokhrel, Timothy Peterson, Deborah J Veis and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Khushpreet KaurDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Yael AlippeDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Chun WangDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Nicholas P SemenkovichData Science Institute, Medical College of Wisconsin; Milwaukee, WsI 53226, USA.
Saumya BhagatDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Kunjan KhannaDepartment of Orthopedic Surgery, Washington University School of Medicine; St. Louis, MO 63110, USA.
Yongjia LiDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Nitin PokhrelDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Timothy PetersonHealth Span Technologies, Inc.; St. Louis, MO, USA.
Deborah J VeisDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.
Yousef Abu-AmerDepartment of Orthopedic Surgery, Washington University School of Medicine; St. Louis, MO 63110, USA.
Roberta FaccioDepartment of Orthopedic Surgery, Washington University School of Medicine; St. Louis, MO 63110, USA.
Gabriel MbalavieleDivision of Bone and Mineral Diseases, Washington University School of Medicine; St. Louis, MO 63110, USA.

Funding

DIABETES &RELATED METABOLIC DISEASEST32DK007120 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Maria Sara Remedi · 1986 to 2026
$15.7M
Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Differential Inflammasome Regulation in the pathogenesis of S. aureus osteomyelitisR01AI161022 · NIAID · WASHINGTON UNIVERSITY · PI CASSAT, JAMES E, MBALAVIELE, GABRIEL · 2021 to 2025
$3.4M
Molecular pathways of calcium pyrophosphate deposition diseaseR01AG077732 · NIA · MEDICAL COLLEGE OF WISCONSIN · PI Gabriel Mbalaviele, Ann K Rosenthal · 2022 to 2026
$2.4M
Regulation of Osteoclastogenesis and Inflammatory OsteolysisR01AR082192 · NIAMS · WASHINGTON UNIVERSITY · PI Yousef Abu-Amer · 2023 to 2026
$1.9M
Role of gasdermin D in bone resorptionR01AR076758 · NIAMS · WASHINGTON UNIVERSITY · PI MBALAVIELE, GABRIEL · 2020 to 2024
$1.9M
Mechanisms of Physiologic and Pathologic OsteoclastogenesisR01AR072623 · NIAMS · WASHINGTON UNIVERSITY · PI ABU-AMER, YOUSEF · 2018 to 2022
$1.7M
Cabinet microCT System for Musculoskeletal Specimen ImagingS10OD028573 · OD · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2020 to 2020
$407k
NIAID NIH HHS R01 AI161022NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR072623NIAMS NIH HHS R01 AR076758NIAMS NIH HHS R01 AR082192NIA NIH HHS R01 AG077732NIDDK NIH HHS T32 DK007120NIH HHS S10 OD028573
6 · The paper itself

Abstract

Osteoclasts (OCs) differentiate from macrophages in response to RANKL. Here, we investigated the role of the NLRP3 inflammasome in mouse macrophages, with or without exposure to RANKL. Unexpectedly, we found that NLRP3 expression gradually declined during osteoclastogenesis but could be restored with LPS treatment. LPS and nigericin robustly activated this inflammasome in macrophages, as expected, but not in OCs. Mechanistically, we identified Tmem178, a protein that restrains Ca

Identifiers

PMID40766650
PMCPMC12324300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.