Evidence map›Paper›PMID 40766640›Full record

ArticlebioRxiv : the preprint server for biology2025

Heterochromatin-based silencing of a foreign tandem repeat in

Tingting Gu, Elena Gracheva, Michael Lee, Wilson Leung, Sophia Bieser, Alixandria Nielsen, Adam T Smiley, Nhi N T Vuong, Matthias Walther, Gunter Reuter and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Tingting GuWashington University in St. Louis, St. Louis, MO 63130.ORCID 0000-0002-0911-5790
Elena GrachevaWashington University in St. Louis, St. Louis, MO 63130.
Michael LeeWashington University in St. Louis, St. Louis, MO 63130.ORCID 0009-0006-7046-6457
Wilson LeungWashington University in St. Louis, St. Louis, MO 63130.ORCID 0000-0002-1371-1915
Sophia BieserWashington University in St. Louis, St. Louis, MO 63130.
Alixandria NielsenBemidji State University and North Hennepin Community College, Brooklyn Park, MN 55445.ORCID 0000-0002-1050-9287
Adam T SmileyBemidji State University and North Hennepin Community College, Brooklyn Park, MN 55445.ORCID 0000-0002-3891-8242
Nhi N T VuongBemidji State University and North Hennepin Community College, Brooklyn Park, MN 55445.ORCID 0000-0002-6201-071X
Matthias WaltherInstitute of Biology, Martin Luther University, Halle (Saale), Germany.
Gunter ReuterInstitute of Biology, Martin Luther University, Halle (Saale), Germany.
Sarah C R ElginWashington University in St. Louis, St. Louis, MO 63130.ORCID 0000-0002-5176-2510
Andrew M ArshamBemidji State University and North Hennepin Community College, Brooklyn Park, MN 55445.ORCID 0000-0002-5274-8710

Funding

REPEAT-INDUCED HETEROCHROMATIN FORMATION IN DROSOPHILAR01GM117340 · NIGMS · WASHINGTON UNIVERSITY · PI DUNCAN, IAN W. · 2016 to 2019
$1.2M
NIGMS NIH HHS R01 GM117340
6 · The paper itself

Abstract

Eukaryotic genomes are packaged into chromatin, a regulatory nucleoprotein assembly. Establishment, maintenance, and interconversion of chromatin states is required for correct patterns of gene expression, genome integrity, and survival. Transcriptionally repressive heterochromatin minimizes mobilization of transposable elements and limits expansion of other repetitive DNA, but mechanisms for recognition of the latter sequences are not well established. We previously demonstrated in

Indexed as

epigenetic regulationheterochromatin licensinghistone deacetylationHP1aPosition Effect Variegation (PEV)

Identifiers

PMID40766640
PMCPMC12324534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.