Evidence map›Paper›PMID 40766629›Full record

ArticlebioRxiv : the preprint server for biology2025

Brain single-cell transcriptional responses to bexarotene-activated RXR in Alzheimer's disease model.

Carolina Saibro-Girardi, Yi Lu, Nicholas F Fitz, Daniel P Gelain, Iliya Lefterov, Radosveta Koldamova

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Carolina Saibro-GirardiORCID 0000-0002-1685-011X
Yi Lu
Nicholas F FitzORCID 0000-0001-6938-6536
Daniel P GelainORCID 0000-0001-5254-0509
Iliya LefterovORCID 0000-0002-0249-0280
Radosveta KoldamovaORCID 0000-0002-6761-0984

Funding

Physical exercise and Blood-brain communication: exosomes, Klotho and choroid plexusR01AG066198 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSIO, FABRISIA, KOLDAMOVA, RADOSVETA · 2020 to 2024
$3.8M
ncRNAs in plasma EVs of AD patients and their discriminatory power as biomarkersRF1AG075992 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLDAMOVA, RADOSVETA, LEFTEROV, ILIYA · 2022 to 2025
$3.7M
The interplay between Tau and ncRNAs – genomic and epigenomic clues to early AD pathogenesisR01AG077636 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RADOSVETA KOLDAMOVA, ILIYA LEFTEROV · 2022 to 2026
$3.5M
APOE Orchestrated Molecular Signatures in Aging Brain and AD-the Contribution of APOE2R01AG057565 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOLDAMOVA, RADOSVETA, LEFTEROV, ILIYA · 2018 to 2022
$3.2M
NIA NIH HHS R01 AG057565NIA NIH HHS R01 AG066198NIA NIH HHS R01 AG077636NIA NIH HHS RF1 AG075992
6 · The paper itself

Abstract

Pharmacological activation of brain Retinoid X Receptors (RXRs) enhances cognition and facilitates amyloid-beta (Aβ) clearance in Alzheimer's disease (AD) mouse models, partly by upregulating Apolipoprotein E (

Identifiers

PMID40766629
PMCPMC12324201

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.