ArticlebioRxiv : the preprint server for biology2025
Uracil-DNA glycosylase deficiency is associated with repressed tumor cell-intrinsic inflammatory signaling and altered sensitivity to exogenous interferons.
Frank P Vendetti, Pinakin Pandya, Carina R Sclafani, Reyna E Jones, Daniel Ivanov, Robert W Sobol, Christopher J Bakkenist
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Frank P VendettiDepartment of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Pinakin PandyaDepartment of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Carina R SclafaniDepartment of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Reyna E JonesDepartment of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Daniel IvanovDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI.
Robert W SobolDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School & Legorreta Cancer Center, Brown University, Providence, RI.ORCID 0000-0001-7385-3563 Christopher J BakkenistDepartment of Radiation Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA.ORCID 0000-0001-9672-0886 Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Leonard J. Appleman · 1988 to 2026
$158.0MResearch Project 3P01ES028949 · NIEHS · FLORIDA GULF COAST UNIVERSITY · PI PARSONS, MICHAEL, SOBOL, ROBERT W · 2018 to 2024
$3.8MNovel approaches to enhance tumor cell cytotoxicity of alkylating agentsR01CA148629 · NCI · UNIVERSITY OF SOUTH ALABAMA · PI SOBOL, ROBERT W · 2010 to 2021
$3.4MInvestigating genetic ancestry influences on oral cavity and laryngeal cancer survival disparitiesR01CA238061 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI RAGIN, CAMILLE C., SOBOL, ROBERT W · 2019 to 2023
$3.4MMeasuring genomic DNA damage and DNA repair capacity in longitudinal population samples - a step towards precision preventionU01ES029518 · NIEHS · UNIVERSITY OF SOUTH ALABAMA · PI SOBOL, ROBERT W · 2018 to 2022
$2.7MThe Impact of ATR Kinase Inhibitors on CD8+ T Cell Expansion and Memory DevelopmentR01CA266172 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 2022 to 2026
$2.3MBarcoded human cells engineered with heterozygous genetic diversity to uncover toxicodynamic variabilityR44ES032522 · NIEHS · AMELIA TECHNOLOGIES, LLC · PI GEORGE, JAY, SOBOL, ROBERT W · 2021 to 2023
$1.9MDNA damage signaling to dormant origins of replicationR01CA236367 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKKENIST, CHRISTOPHER J. · 2020 to 2024
$1.8MNCI NIH HHS P30 CA047904NCI NIH HHS R01 CA148629NCI NIH HHS R01 CA236367NCI NIH HHS R01 CA238061NCI NIH HHS R01 CA266172NIEHS NIH HHS P01 ES028949NIEHS NIH HHS R44 ES032522NIEHS NIH HHS U01 ES029518
6 · The paper itselfAbstract
2'-deoxyuridine (dU) is a common DNA lesion resulting from cytosine deamination and from dUMP incorporation by DNA polymerases, both of which are prevalent in cancer. The primary mechanism that repairs dU lesions in genomic DNA is base excision repair initiated by Uracil-DNA Glycosylase 1 (UNG1). We generated
Indexed as
deoxyuridineglycosylasetumor microenvironmenttype-II interferontype-I interferonUNG
Identifiers
PMID40766605
PMCPMC12324335
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