Evidence map›Paper›PMID 40766594›Full record

ArticlebioRxiv : the preprint server for biology2025

BBSome-Mediated Clearance of Ubiquitinated IMPG2 Defines a Constitutive Ciliary Retrieval Pathway in Photoreceptors.

Tirthasree Das, Gary A Bradshaw, Jeanette Hyer, Markus Masek, Yien-Ming Kuo, Ruxandra Bachmann-Gagescu, Marian Kalocsay, Maxence V Nachury

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tirthasree DasDepartment of Ophthalmology, University of California San Francisco, CA 94143, USA.
Gary A BradshawDepartment of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Jeanette HyerDepartment of Ophthalmology, University of California San Francisco, CA 94143, USA.
Markus MasekInstitute of Medical Genetics, University of Zurich, Schlieren, Switzerland.
Yien-Ming KuoDepartment of Ophthalmology, University of California San Francisco, CA 94143, USA.
Ruxandra Bachmann-GagescuInstitute of Medical Genetics, University of Zurich, Schlieren, Switzerland.
Marian KalocsayDepartment of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
Maxence V NachuryDepartment of Ophthalmology, University of California San Francisco, CA 94143, USA.ORCID 0000-0003-4918-1562

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ULLIAN, ERIK M · 1985 to 2024
$16.8M
Quality control of the primary cilium proteomeR01GM089933 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Maxence V Nachury · 2010 to 2026
$5.8M
Structural basis of BBSome-mediated ciliary exitR01EY031462 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NACHURY, MAXENCE V, WALZ, THOMAS · 2020 to 2023
$2.8M
NEI NIH HHS P30 EY002162NEI NIH HHS R01 EY031462NIGMS NIH HHS R01 GM089933
6 · The paper itself

Abstract

The BBSome mediates the retrieval of ubiquitinated membrane proteins from cilia, but its physiological cargoes in photoreceptors remain largely unidentified. Here, we find that K63-linked ubiquitin (UbK63) chains accumulate in the outer segment (OS, equivalent of cilia) of

Identifiers

PMID40766594
PMCPMC12324355

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.