Evidence map›Paper›PMID 40766592›Full record

ArticlebioRxiv : the preprint server for biology2025

Multi-omic analyses identify molecular targets of Chd7 that mediate CHARGE syndrome model phenotypes.

Melody B Hancock, Dana R Ruby, Rachael A Bieler, David C Cole, Kurt C Marsden

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Melody B HancockNorth Carolina State University.
Dana R RubyNorth Carolina State University.
Rachael A BielerNorth Carolina State University.
David C ColeNorth Carolina State University.
Kurt C MarsdenNorth Carolina State University.ORCID 0000-0001-8087-6181

Funding

Molecular and Cellular Mechanisms of Acoustic Startle Threshold RegulationR01NS116354 · NINDS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MARSDEN, KURT C. · 2021 to 2025
$1.9M
Cellular and Molecular Mechanisms of Behavioral Dysfunction in a Zebrafish Model of CHARGE SyndromeR21NS120079 · NINDS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI MARSDEN, KURT C. · 2021 to 2021
$411k
NINDS NIH HHS R01 NS116354NINDS NIH HHS R21 NS120079
6 · The paper itself

Abstract

CHARGE syndrome is a developmental disorder that affects 1 in 10,000 births, and patients exhibit both physical and behavioral characteristics.

Identifiers

PMID40766592
PMCPMC12324285

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.