Evidence map›Paper›PMID 40766575›Full record

ArticlebioRxiv : the preprint server for biology2025

Condition-dependent effects of knockdown of autophagy on

Kuei Ching Hsiung, Hannah Chapman, Xiaoya Wei, Xiaoyu Sun, Isadora Rawlinson, David Gems

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kuei Ching HsiungInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0002-2107-6368
Hannah ChapmanInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.
Xiaoya WeiInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.
Xiaoyu SunInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.
Isadora RawlinsonInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.
David GemsInstitute of Healthy Ageing, and Research Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0002-6653-4676

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440Wellcome Trust
6 · The paper itself

Abstract

Autophagy is thought to clear damaged cellular constituents that contribute to aging, and several life-extending interventions in model organisms show some degree of autophagy dependence. In

Indexed as

agingcondition dependencegermlineinsulin/IGF-1 signalingnematode

Identifiers

PMID40766575
PMCPMC12324348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.