ArticlebioRxiv : the preprint server for biology2025
Altered Gut Microbiota Mediates the Association between APOE Genotype and Amyloid-β Accumulation in Middle-Aged Adults.
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Importance: The apolipoprotein E ( Objective: To evaluate whether specific microbial taxa mediate APOE-related effects on brain Aβ burden in an established population-based study of middle-aged adults. Design Setting and Participants: This cross-sectional study analyzed data from the Framingham Heart Study cohort. Data were collected at the third examination visit (n = 227, %Female = 58, mean age = 56.5 ± 8.3), between 2016 and 2019. Exposures: Gut bacterial DNA was sequenced using 16S rRNA, and amplicon sequence variants (ASVs) were agglomerated at various taxonomic levels (14 phyla, 70 families, and ∼140 genera). Main Outcomes and Measures: Overall and regional measures of cerebral amyloid-β deposition were assessed using carbon-11 Pittsburgh (PiB) Compound-B PET scans. The global PiB deposition served as the primary outcome for " Results: A higher Aβ burden was significantly associated with the depletion of protective genera (e.g., Conclusion and Relevance: Gut microbiome composition partially mediates the relationship between
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