Evidence map›Paper›PMID 40766554›Full record

ArticlebioRxiv : the preprint server for biology2025

Distinct Colitis-Associated Macrophages Drive NOD2-Dependent Bacterial Sensing and Gut Homeostasis.

Gajanan D Katkar, Mahitha Shree Anandachar, Stella-Rita Ibeawuchi, Ella McLaren, Megan Estanol, Kennith Carpio-Perkins, Shu-Ting Hsu, Celia R Espinoza, Jane Coates, Yashaswat S Malhotra and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Gajanan D KatkarDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Mahitha Shree AnandacharDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Stella-Rita IbeawuchiDepartment of Pathology, University of California San Diego, CA, USA.
Ella McLarenDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Megan EstanolDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Kennith Carpio-PerkinsDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Shu-Ting HsuDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Celia R EspinozaDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Jane CoatesDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Yashaswat S MalhotraDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Madhubanti MullickDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Vanessa CastilloDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Daniella T VoDepartment of Pediatrics, University of California San Diego, CA, USA.
Saptarshi SinhaDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.
Pradipta GhoshDepartment of Cellular and Molecular Medicine, University of California San Diego, CA, USA.

Funding

GRADUATE TRAINING PROGRAM IN BIONFORMATICST32GM008806 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BAFNA, VINEET, REN, BING · 2001 to 2020
$6.2M
Modulation of Macrophage Polarization by Heterotrimeric G proteins: Implications of Gastrointestinal InflammationR01AI141630 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Pradipta Ghosh · 2019 to 2026
$3.2M
Innate responses following infection with enteric microbesR01DK107585 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA · 2016 to 2020
$2.2M
Network-Based Novel Therapeutics in Colorectal CancersUG3TR002968 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2019 to 2021
$946k
Precision therapeutics of inflammatory bowel disease guided by Boolean logicUG3TR003355 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAS, SOUMITA, GHOSH, PRADIPTA · 2020 to 2022
$937k
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
JEOL JEM-1400Plus Transmission Electron MicroscopeS10OD023527 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FARQUHAR, MARILYN GIST · 2017 to 2017
$579k
NCATS NIH HHS UG3 TR002968NCATS NIH HHS UG3 TR003355NIAID NIH HHS R01 AI141630NIDDK NIH HHS R01 DK107585NIGMS NIH HHS T32 GM008806NIH HHS S10 OD023527NIH HHS S10 OD026929
6 · The paper itself

Abstract

Single-cell studies have revealed that intestinal macrophages maintain gut homeostasis through the balanced actions of reactive (inflammatory) and tolerant (non-inflammatory) subpopulations. How such balance is impaired in inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remains unresolved. Here, we define colon-specific macrophage states and reveal the critical role of

Indexed as

CCDC88AGIV/GirdinGuanine-nucleotide exchange modulators (GEMs)Innate immunityMacrophageMDPMicrobesNOD2

Identifiers

PMID40766554
PMCPMC12324400

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.