Evidence map›Paper›PMID 40766534›Full record

ArticlebioRxiv : the preprint server for biology2025

A microsporidial deubiquitinase blocks ubiquitin transfer from adenylated E1 to human UBE2K ubiquitin conjugating enzyme.

Tomiwa Lawal, Alana H Chang, Lauren G Carnley, Nehry Y Celoge, Taylor A Blount, Cynthia Vied, Antonia A Nemec, Robert J Tomko

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomiwa LawalDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Alana H ChangDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Lauren G CarnleyDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Nehry Y CelogeDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Taylor A BlountDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Cynthia ViedTranslational Science Laboratory, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Antonia A NemecDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.
Robert J TomkoDepartment of Biomedical Sciences, Florida State University College of Medicine, Tallahassee, FL, USA 32306.ORCID 0000-0003-2515-1078

Funding

Engagement and Communication Between Proteasonal SubcomplexesR01GM118600 · NIGMS · FLORIDA STATE UNIVERSITY · PI ROBERT JOSEPH TOMKO · 2017 to 2026
$2.7M
NIGMS NIH HHS R01 GM118600
6 · The paper itself

Abstract

Intracellular pathogens frequently subjugate the ubiquitin system to evade host immune defenses and establish intracellular replication niches. Microsporidia are obligate intracellular animal parasites that typically cause self-limiting infections in humans, but can sometimes cause fatal disseminated disease. At present, the ubiquitin system of microsporidia is virtually unexplored. Here, we discover a likely effector deubiquitinase (DUB) of the otubain subgroup from the human pathogenic microsporidian

Identifiers

PMID40766534
PMCPMC12324444

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.