ArticlebioRxiv : the preprint server for biology2025
Lower-order methylation states underlie the maintenance and re-establishment of Polycomb modifications in
Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polycomb Group (PcG) proteins regulate the chromatin composition of an embryo by facilitating the mono, di, and tri-methylation of Histone H3 Lysine 27 (H3K27me1/2/3). For the zygote to inherit an H3K27 methylation blueprint from its mother, PcG-modified states established during oogenesis must persist through early embryogenesis until the onset of large-scale zygotic transcription (Zygotic Genome Activation, ZGA). However, questions have persisted regarding the relative contributions of two molecular mechanisms to the propagation of H3K27 methylation through early development: 1) allosteric regulation of the H3K27 methyltransferase Enhancer of Zeste (
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