Evidence map›Paper›PMID 40766508›Full record

ArticlebioRxiv : the preprint server for biology2025

A Sequence Motif Enables Widespread Use of Non-Canonical Redox Cofactors in Natural Enzymes.

Samer Saleh, Ning-Hsiang Hsu, Emma Luu, Vincent C Martin, Hans Jefferson C Ng, William B Black, Jin-Kwang Kim, Banumathi Sankaran, Ryan L Hayes, Justin B Siegel and 2 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Samer SalehDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0009-0004-3460-4643
Ning-Hsiang HsuDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0009-0003-9443-7026
Emma LuuGenome Center, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-0388-9330
Vincent C MartinDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0009-0007-2798-2066
Hans Jefferson C NgDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
William B BlackDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.ORCID 0009-0007-2851-9997
Jin-Kwang KimDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.
Banumathi SankaranMolecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.ORCID 0000-0002-3266-8131
Ryan L HayesDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.
Justin B SiegelGenome Center, University of California, Davis, Davis, CA, USA.
Feng QiaoDepartment of Biological Chemistry, University of California, Irvine, Irvine, CA, USA.ORCID 0000-0002-1704-7257
Han LiDepartment of Chemical and Biomolecular Engineering, University of California, Irvine, Irvine, CA, USA.

Funding

Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI YOUNG, THOMAS MICHAEL · 1987 to 2021
$50.1M
X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversityR01GM076324 · NIGMS · IOWA STATE UNIVERSITY · PI PETERS, REUBEN JOHN · 2006 to 2019
$3.4M
Expanding the Metabolic Currencies of LifeR35GM153401 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Han Li · 2024 to 2026
$1.4M
NIEHS NIH HHS P42 ES004699NIGMS NIH HHS P30 GM124169NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM076324NIGMS NIH HHS R35 GM153401
6 · The paper itself

Abstract

Non-canonical redox cofactors (NRCs) are promising alternatives to nicotinamide adenine dinucleotide (phosphate) (NAD(P)

Indexed as

Active site pre-organizationAldehyde dehydrogenaseBiomimetic nicotinamide coenzymeEnzyme engineeringNicotinamide mononucleotideNon-canonical redox cofactor

Identifiers

PMID40766508
PMCPMC12324450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.