Evidence map›Paper›PMID 40766494›Full record

ArticlebioRxiv : the preprint server for biology2025

IMPACTS OF DNA METHYLATION ON H2A.Z DEPOSITION AND NUCLEOSOME STABILITY.

Rochelle M Shih, Yasuhiro Arimura, Hide A Konishi, Hironori Funabiki

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Rochelle M ShihLaboratory of Chromosome and Cell Biology, The Rockefeller University, New York, New York, 10065, USA.ORCID 0000-0002-3218-4479
Yasuhiro ArimuraLaboratory of Chromosome and Cell Biology, The Rockefeller University, New York, New York, 10065, USA.ORCID 0000-0002-1903-6076
Hide A KonishiLaboratory of Chromosome and Cell Biology, The Rockefeller University, New York, New York, 10065, USA.ORCID 0000-0001-9529-9321
Hironori FunabikiLaboratory of Chromosome and Cell Biology, The Rockefeller University, New York, New York, 10065, USA.ORCID 0000-0003-4831-4087

Funding

Regulation of mitotic chromosomes - Revision - 2R35GM132111 · NIGMS · ROCKEFELLER UNIVERSITY · PI Hironori Funabiki · 2019 to 2026
$6.9M
NIGMS NIH HHS R35 GM132111
6 · The paper itself

Abstract

In eukaryotes with DNA methylation, the histone variant H2A.Z and DNA methylation are maintained in mutually exclusive sections of the genome. How this antagonism is established, however, remains an open question. Here, we examined the impacts of DNA methylation on both the intrinsic stability of H2A.Z nucleosomes and chaperone-mediated H2A.Z deposition. Cryo-EM and endonuclease accessibility analyses show that H2A.Z nucleosomes with methylated DNA are more open and accessible compared to their unmethylated counterparts. In

Identifiers

PMID40766494
PMCPMC12324538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.