Evidence map›Paper›PMID 40766486›Full record

ArticlebioRxiv : the preprint server for biology2026

Fibroblast depletion reveals mammalian epithelial resilience across neonatal and adult stages.

Isabella M Gaeta, Shuangshuang Du, Clémentine Villeneuve, David G Gonzalez, Catherine Matte-Martone, Smirthy Ganesan, Deandra Simpson, Hilldana Tibebu, Jessica L Moore, Chen Yuan Kam and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Isabella M GaetaDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.ORCID 0000-0001-7806-3616
Shuangshuang DuDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Clémentine VilleneuveDepartment of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
David G GonzalezDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Catherine Matte-MartoneDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Smirthy GanesanDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Deandra SimpsonDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Hilldana TibebuDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Jessica L MooreDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Chen Yuan KamDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Sara GalliniDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Haoyang WeiDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Fabien BertillotDepartment of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
Dagmar ZeuschnerElectron Microscopy Facility, Max Planck Institute for Molecular Biomedicine, 48149, Muenster, Germany.
Lauren E GonzalezDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Ushnish RanaDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.ORCID 0000-0001-6783-6193
Kaelyn D SumigrayDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.
Sara A WickströmDepartment of Cell and Tissue Dynamics, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.
Valentina GrecoDepartment of Genetics, Yale School of Medicine, New Haven, CT 06510 USA.ORCID 0000-0002-6492-4603

Funding

Live Imaging of Skin RegenerationR01AR063663 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2012 to 2026
$7.7M
Understanding Skin Tissue Repair in Live MammalsR01AR072668 · NIAMS · YALE UNIVERSITY · PI Valentina Greco · 2018 to 2026
$6.2M
Defining the role of mutational burden in sustaining normal homeostasis during agingDP1AG066590 · NIA · YALE UNIVERSITY · PI GRECO, VALENTINA · 2019 to 2023
$5.9M
Normal stem cells and their transition to disease in the skinR01AR067755 · NIAMS · YALE UNIVERSITY · PI GRECO, VALENTINA · 2016 to 2020
$2.2M
NIAMS NIH HHS R01 AR063663NIAMS NIH HHS R01 AR067755NIAMS NIH HHS R01 AR072668NIA NIH HHS DP1 AG066590
6 · The paper itself

Abstract

Regenerative organs, like the skin, depend on niche-stem cell interactions that sustain continuous cellular turnover. In cell culture, skin fibroblasts promote epidermal stem cell proliferation and differentiation. Yet, it remains elusive how fibroblasts regulate epidermal stem cell behaviors and differentiation in skin

Identifiers

PMID40766486
PMCPMC12324404

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.