Evidence map›Paper›PMID 40766485›Full record

ArticlebioRxiv : the preprint server for biology2025

A Meta-Analysis of the Effects of Acute Sleep Deprivation on the Cortical Transcriptome in Rodent Models.

Cosette A Rhoads, Megan H Hagenauer, Jinglin Xiong, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Elizabeth Flandreau, Stanley Watson, Huda Akil

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Cosette A RhoadsGrinnell College, Grinnell, IA USA.ORCID 0009-0007-8670-7814
Megan H HagenauerMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.ORCID 0000-0002-3715-9475
Jinglin XiongGrinnell College, Grinnell, IA USA.ORCID 0009-0007-0015-0796
Erin HernandezGrinnell College, Grinnell, IA USA.ORCID 0009-0004-4468-7921
Duy Manh NguyenGrinnell College, Grinnell, IA USA.ORCID 0000-0002-5497-3954
Annaka SaffronJohns Hopkins University, Baltimore, MD USA.ORCID 0009-0002-4859-4082
Elizabeth FlandreauGrand Valley State University, Allendale, MI USA.ORCID 0000-0003-3634-1694
Stanley WatsonMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.ORCID 0000-0003-4980-5523
Huda AkilMichigan Neuroscience Institute, University of Michigan, Ann Arbor, MI USA.ORCID 0000-0003-0623-1056

Funding

Investigating the role of Bmp4 in glial subtype specification and temperamentU01DA043098 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HUDA AKIL, Jun Li · 2017 to 2026
$6.9M
NIDA NIH HHS U01 DA043098
6 · The paper itself

Abstract

Sleep deprivation (SD) causes large disturbances in mood and cognition. The molecular basis for these effects can be explored using transcriptional profiling to quantify brain gene expression. In this report, we used a meta-analysis of public transcriptional profiling data to discover SD effects on gene expression that are consistent across studies and paradigms. To conduct the meta-analysis, we used pre-specified search terms related to rodent SD paradigms to identify relevant studies within

Indexed as

Cerebral CortexMeta-AnalysisMicroarrayRNA-SeqSleep

Identifiers

PMID40766485
PMCPMC12324401

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.