Evidence map›Paper›PMID 40766457›Full record

ArticlebioRxiv : the preprint server for biology2025

Surveillance on California dairy farms reveals multiple sources of H5N1 transmission.

A J Campbell, Meredith Shephard, Abigail P Paulos, Matthew Pauly, Michelle Vu, Chloe Stenkamp-Strahm, Kaitlyn Bushfield, Betsy Hunter-Binns, Orlando Sablon, Emily E Bendall and 14 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

A J CampbellDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0003-4780-0227
Meredith ShephardDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0003-4035-6653
Abigail P PaulosGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA.ORCID 0009-0001-9258-6648
Matthew PaulyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-6710-7142
Michelle VuDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-3208-710X
Chloe Stenkamp-StrahmDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO.ORCID 0000-0001-5963-2596
Kaitlyn BushfieldDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0009-0006-6738-7168
Betsy Hunter-BinnsMilk Producers Council, Ontario, CA.
Orlando SablonGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA.
Emily E BendallDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-2524-088X
William J FitzimmonsDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Kayla BrizuelaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0009-0004-3929-7080
Gracie QuirkDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0009-0006-3327-1511
Nirmal KumarDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Brian McCluskeyDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO.
Nishit ShettyDepartment of Civil, Environmental and Architectural Engineering, University of Kansas, Lawrence, KS.ORCID 0000-0002-0488-7716
Linsey C MarrDepartment of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA.ORCID 0000-0003-3628-6891
Jenna J GuthmillerDepartment of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO.ORCID 0000-0001-7566-3536
Kevin AbernathyMilk Producers Council, Ontario, CA.
Adam S LauringDivision of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor, MI.ORCID 0000-0003-2906-8335
Blaine T MelodyLander Veterinary Clinic, Turlock, CA.
Marlene WolfeGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA.
Jason LombardDepartment of Clinical Sciences, Colorado State University, Fort Collins, CO.
Seema S LakdawalaDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0002-7679-2150

Funding

The Michigan Infectious Disease Genomics (MIDGE) CenterU19AI181767 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAURING, ADAM, SNITKIN, EVAN · 2024 to 2024
$6.2M
NIAID NIH HHS U19 AI181767
6 · The paper itself

Abstract

Transmission routes of highly pathogenic H5N1 between cows or to humans remain unclear due to limited data from affected dairy farms. We performed extensive air, farm wastewater, and milk sampling on 14 H5N1 positive dairy farms across two different California regions. Virus was detected in the air in milking parlors and from exhaled breath of cows. Infectious H5N1 virus was detected in the air and water streams; sequence analysis revealed viral variants on a farm in these locations. Longitudinal analysis of milk from the individual quarters of cows revealed a high prevalence of subclinical H5N1 positive cows and a heterogeneous distribution of infected quarters that maintained a consistent pattern over time. Our data highlight potential modes of H5N1 transmission on dairy farms.

Identifiers

PMID40766457
PMCPMC12324433

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.