Evidence map›Paper›PMID 40766450›Full record

ArticlebioRxiv : the preprint server for biology2025

CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk.

Roger B Dodd, Masahiro Enomoto, Ye Zhou, Kanayo Satoh, Yalun Zhang, Fusheng Chen, Beatrice Acheson, Deniz Ghaffari, Elizabeth Sayn-Wittgenstein, Jamie J Manning and 40 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

50 authors.

Roger B Dodd
Masahiro Enomoto
Ye Zhou
Kanayo Satoh
Yalun Zhang
Fusheng Chen
Beatrice Acheson
Deniz Ghaffari
Elizabeth Sayn-Wittgenstein
Jamie J Manning
George V Dukas
Ronak Patel
Alondra Schweizer Burguete
Mason J Kralovec
Mamunur Rashid
Jennifer L Hall
Kirstin A Tamucci
Minghua Liu
Annie J Lee
Badri N Vardarajan
Mariko F Taga
Sirkku Pollari
Alon Rabinovitch
Cory D Rillahan
Andrey A Bobkov
Eduard Sergienko
William Meadows
Seema Qamar
Suzanne J Randle
Christopher M Johnson
Jean Sevalle
Jennifer Griffin
Christopher Bohm
Mitsuhiko Ikura
Xunde Xian
Joachim Herz
Megan A Kelly
Jennifer West
Sandeep Satapathy
Jonathan A Javitch
Paul E Fraser
David A Bennett
Philip L De JagerORCID 0000-0002-8057-2505
Zvi Fishelson
Dan Frenkel
Wesley B Asher
Elizabeth M Bradshaw
Peter St George-Hyslop

Funding

Research Education CoreP30AG066462 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Christiane Reitz · 2020 to 2026
$30.1M
High Throughput Screen to Discover Modulators of TREM2 ActivityR01AG058446 · NIA · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI JACKSON, MICHAEL · 2018 to 2020
$1.3M
Genetic Association Between Alzheimer's Disease and Cardio-Cerebrovascular Risk FactorsK01AG084849 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Annie J Lee · 2024 to 2026
$377k
NIA NIH HHS K01 AG084849NIA NIH HHS P30 AG066462NIA NIH HHS R01 AG058446
6 · The paper itself

Abstract

We report the results of structural, functional and genetic studies on the CD33 sialic acid- binding receptor that reveal how non-coding variants in CD33 alter risk for Alzheimer's disease (AD). The full-length CD33

Identifiers

PMID40766450
PMCPMC12324352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.