Evidence map›Paper›PMID 40766427›Full record

ArticlebioRxiv : the preprint server for biology2025

Sigma-1 Receptor Promotes Glycolysis in Neuronal Systems by Suppressing GRIM19.

Simon Couly, Yuko Yasui, Ioannis Grammatikakis, Yuriko Kimura, Josh Hinkle, Juan Gomez, Hsiang-En Wu, Ghosh Paritosh, Ashish Lal, Michael Michaelides and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Simon CoulyCellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Suite 3512, 333 Cassell Drive, Baltimore, MD, 21224, USA.
Yuko YasuiCellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Suite 3512, 333 Cassell Drive, Baltimore, MD, 21224, USA.
Ioannis GrammatikakisRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA.
Yuriko KimuraCellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Suite 3512, 333 Cassell Drive, Baltimore, MD, 21224, USA.
Josh HinkleCellular Stress and Inflammation Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Biomedical Research Center 251 Bayview Boulevard, Baltimore, MD, 21224, USA.
Juan GomezBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Biomedical Research Center 251 Bayview Boulevard, Baltimore, MD, 21224, USA.ORCID 0000-0003-3170-9904
Hsiang-En WuCellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Suite 3512, 333 Cassell Drive, Baltimore, MD, 21224, USA.
Ghosh ParitoshLaboratory of Clinical Investigation, National Institute on Aging, NIH/DHHS, Baltimore, MD, USA.
Ashish LalRegulatory RNAs and Cancer Section, Genetics Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), Bethesda, MD 20892, USA.
Michael MichaelidesBiobehavioral Imaging and Molecular Neuropsychopharmacology Section, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Biomedical Research Center 251 Bayview Boulevard, Baltimore, MD, 21224, USA.
Brandon HarveyCellular Stress and Inflammation Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Biomedical Research Center 251 Bayview Boulevard, Baltimore, MD, 21224, USA.
Tsung-Ping SuCellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, NIH/DHHS, Suite 3512, 333 Cassell Drive, Baltimore, MD, 21224, USA.

Funding

Biobehavioral Imaging and Molecular Neuropsychopharmacology of Substance Abuse MechanismsZIADA000069 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI MICHAELIDES, MICHAEL · 2016 to 2025
$18.9M
Intramural NIH HHS ZIA DA000069
6 · The paper itself

Abstract

Sigma-1 receptor (S1R) is a Ca

Indexed as

energy metabolismglycolysismitochondrianeuronsnicotinamide adenine dinucleotide (NAD)Sigma-1 receptor

Identifiers

PMID40766427
PMCPMC12324332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.