In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
14 authors.
Scott R KennedyUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0002-4444-1145 Brendan F KohrnUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0001-9948-2131 Pavlo LazarchukUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.
Mario LeutertUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0001-7921-4017 Monica Sanchez-ContrerasUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0002-3092-2781 Weiliang TangUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0002-2460-2677 Jerome J GraberUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.
Judit VillénUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0002-1005-1739 Raymond J MonnatUniversity of Washington Departments of Laboratory Medicine and Pathology (BK, SK, MS-C and RM); Genome Sciences (ML, RM, JV); Bioengineering (RM); and Neurology and Neurosurgery (JG), Seattle WA.ORCID 0000-0001-7638-7393 Funding
Tumor mutation signaturesP01CA077852 · NCI · UNIVERSITY OF WASHINGTON · PI LOEB, LAWRENCE A · 1999 to 2019
$26.0MInvestigating the landscape and genetic architecture of germline mutagenesisR35GM133428 · NIGMS · UNIVERSITY OF WASHINGTON · PI Kelley Harris · 2019 to 2026
$2.8MThe role of phosphorylation in the cellular organization of the proteomeR35GM152061 · NIGMS · UNIVERSITY OF WASHINGTON · PI Judit Villen · 2024 to 2026
$1.3MUnderstanding the regulation of mtDNA heteroplasmy and integrityR35GM153370 · NIGMS · UNIVERSITY OF WASHINGTON · PI Scott Robert Kennedy · 2024 to 2026
$1.2MMassively Parallel Single Cell Detection of Rare Variants with Split-Pool Combinatorial IndexingR21HG011229 · NHGRI · UNIVERSITY OF WASHINGTON · PI KENNEDY, SCOTT ROBERT, SEELIG, GEORG · 2020 to 2020
$622kExploiting Urine Derived DNA for the Assessment of Bladder Cancer using High Accuracy SequencingR21CA259780 · NCI · UNIVERSITY OF WASHINGTON · PI KENNEDY, SCOTT ROBERT · 2021 to 2022
$395kNCI NIH HHS P01 CA077852NCI NIH HHS R21 CA259780NHGRI NIH HHS R21 HG011229NIGMS NIH HHS R35 GM133428NIGMS NIH HHS R35 GM152061NIGMS NIH HHS R35 GM153370
6 · The paper itselfAbstract
Glioblastoma stem cell (GSC) cultures are initiated from glioblastoma (GBM) surgical resection tissue. They can capture and propagate key GBM primary tumor molecular and cellular features. We have deeply characterized four isocitrate dehydrogenase (IDH)-expressing (or IDH+) GSC cultures from unrelated adults to serve as cellular models for the majority of adult primary GBM. We demonstrate that GSC cultures can be continuously propagated in defined, serum-free media and 5% oxygen without requiring specialized growth substrates; have well-defined genomic and mtDNA variants and gene/protein expression profiles; and highly reproducible dose-survival curves when treated with the GBM standard-of-care therapies of ionizing radiation (IR) and temozolomide (TMZ). We also illustrate how expressed lentiviral barcodes, mtDNA variants and single cell gene expression profiling can be used to define and track cellular heterogeneity over 40 days after IR treatment. These well-characterized IDH+ GSC cultures can support many high throughput
Indexed as
cellular heterogeneityDuplex DNA sequencingexome sequencingexpressed lentiviral DNA barcodeglioblastomaglioma stem cellionizing radiationMS-MS proteomic profilingmtDNA variantsingle cell RNA sequencingtemozolomide
Identifiers
PMID40766425
PMCPMC12324346
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