Evidence map›Paper›PMID 40766417›Full record

ArticlebioRxiv : the preprint server for biology2025

UBR-1 enzyme network regulates glutamate homeostasis to affect organismal behavior and developmental viability.

Joseph S Pak, Seamus Morrone, Karla J Opperman, Mukul K Midha, Charu Kapil, Neal D Mathew, Damon T Page, Ning Zheng, Robert L Moritz, Brock Grill

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joseph S PakNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, WA 98101.
Seamus MorroneInstitute for Systems Biology, Seattle, WA 98109.
Karla J OppermanNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, WA 98101.
Mukul K MidhaInstitute for Systems Biology, Seattle, WA 98109.ORCID 0000-0003-4053-0682
Charu KapilInstitute for Systems Biology, Seattle, WA 98109.ORCID 0000-0002-8750-5006
Neal D MathewNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, WA 98101.
Damon T PageNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, WA 98101.
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA 98195.ORCID 0000-0002-1039-1581
Robert L MoritzInstitute for Systems Biology, Seattle, WA 98109.ORCID 0000-0002-3216-9447
Brock GrillNorcliffe Foundation Center for Integrative Brain Research, Seattle Children's Hospital, Seattle, WA 98101.ORCID 0000-0002-0379-3267

Funding

Shortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0M
Regulation of Opioid Sensitivity and Tolerance by Ubiquitin Ligase SignalingR01DA056370 · NIDA · SEATTLE CHILDREN'S HOSPITAL · PI Brock Grill, NING ZHENG · 2022 to 2026
$3.1M
Acquisition of Fusion Lumos Orbitrap mass spectrometerS10OD026936 · OD · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2019 to 2019
$600k
Regulation of nervous system health and function by the E3 ligase UBR-1F32GM156113 · NIGMS · SEATTLE CHILDREN'S HOSPITAL · PI PAK, JOSEPH · 2024 to 2024
$74k
NIDA NIH HHS R01 DA056370NIGMS NIH HHS F32 GM156113NIGMS NIH HHS R01 GM087221NIH HHS S10 OD026936
6 · The paper itself

Abstract

Johanson-Blizzard Syndrome (JBS) is an autosomal recessive spectrum disorder associated with the UBR-1 ubiquitin ligase that features developmental delay including motor abnormalities. Here, we demonstrate that

Identifiers

PMID40766417
PMCPMC12324394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.