Evidence map›Paper›PMID 40766408›Full record

ArticlebioRxiv : the preprint server for biology2025

Steric control of signaling bias in the immunometabolic receptor GPR84.

Pinqi Wang, Xuan Zhang, Abdul-Akim Guseinov, Laura Jenkins, Carl von Hallerstein, Jonathan D Colburn, Rowan Ives, Vincent B Luscombe, Sara Marsango, Listiana Oktavia and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pinqi WangDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0009-0007-1160-1206
Xuan ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, U.S.A.
Abdul-Akim GuseinovSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
Laura JenkinsSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Carl von HallersteinDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, U.K.
Jonathan D ColburnDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, U.K.ORCID 0000-0001-9613-1045
Rowan IvesDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.
Vincent B LuscombeSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.ORCID 0000-0002-2886-4017
Sara MarsangoSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.ORCID 0000-0002-0590-7942
Listiana OktaviaDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0002-8664-4506
Arun RajaDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0002-4060-2490
David R GreavesSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, U.K.ORCID 0000-0003-2856-9410
Philip C BigginDepartment of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, U.K.
Graeme MilliganSchool of Molecular Biosciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, U.K.
Cheng ZhangDepartment of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, U.S.A.
Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, Northern Ireland, U.K.
Angela J RussellDepartment of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K.ORCID 0000-0003-3610-9369

Funding

Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammationR35GM128641 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHENG ZHANG · 2018 to 2026
$3.5M
Cryo-electron microscopeS10OD025009 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2018 to 2018
$2.0M
Direct electron detecting (DED) cameraS10OD019995 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2015 to 2015
$548k
NIGMS NIH HHS R35 GM128641NIH HHS S10 OD019995NIH HHS S10 OD025009Wellcome Trust
6 · The paper itself

Abstract

Biased signaling in G protein-coupled receptors offers therapeutic promise, yet rational design of biased ligands remains challenging due to limited mechanistic understanding. Here, we report a molecular framework for controlling signaling bias at the immunometabolic receptor GPR84. We identified three structurally-matched ligands (OX04529, OX04954, and OX04539) with varying steric profiles that exhibit comparable G

Identifiers

PMID40766408
PMCPMC12324463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.