Evidence map›Paper›PMID 40766397›Full record

ArticlebioRxiv : the preprint server for biology2025

The Alzheimer's disease risk gene

C Andrew Williams, Shannon E Rose, Vera Stamenkovic, Stephen E P Smith, Jessica E Young

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

C Andrew WilliamsDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Shannon E RoseDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.
Vera StamenkovicCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
Stephen E P SmithCenter for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.ORCID 0000-0003-4180-573X
Jessica E YoungDepartment of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA.ORCID 0000-0003-2106-0339

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0M
Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Characterization of AD-related endolysosomal dysfunction in human neural cellsR01AG080585 · NIA · UNIVERSITY OF WASHINGTON · PI SUMAN JAYADEV, Jessica E Young · 2024 to 2026
$2.5M
NIA NIH HHS P30 AG066509NIA NIH HHS R01 AG080585NIA NIH HHS T32 AG052354
6 · The paper itself

Abstract

Background: Synaptic dysfunction is an early feature of Alzheimer's disease (AD) and a significant contributor to cognitive decline and neurodegeneration. Proper localization of proteins involved in pre-and post-synaptic composition is dependent on endosomal recycling and trafficking. Alterations in trafficking complexes, such as retromer, have been shown to impair neuronal synaptic function. The Methods: We utilized our established human induced pluripotent stem cell (hiPSC) derived excitatory cortical neuron model to examine Results: We show that loss of Conclusions: These findings further support a growing body of literature implicating early endosomal recycling defects as drivers of AD pathogenesis. Furthermore, our work supports further emphasis on exploring the SORL1-retromer pathway for therapeutic development in AD.

Indexed as

Alzheimer’s diseaseAmyloid beta peptideEndosomal traffickingGlutamate receptoriPSC-derived neuronsNeuronal hyperactivityRetromerSORL1SORLASynapseSynaptic plasticity

Identifiers

PMID40766397
PMCPMC12324333

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.