Evidence map›Paper›PMID 40766395›Full record

ArticlebioRxiv : the preprint server for biology2025

Decoding Cellular Stress States for Toxicology Using Single-Cell Transcriptomics.

Imran Shah, David Gallegos, Brian Robinette, Bryant A Chambers, Dennis J Eastburn, Douglas A Bell, Michelle R Campbell, Suzanne N Martos, Salvatore Camiolo, Kevin S White and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Imran ShahCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.ORCID 0000-0003-0808-0140
David GallegosCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Brian RobinetteCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.
Bryant A ChambersCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-2233-3207
Dennis J EastburnBioSpyder, Inc., Carlsbad, California, USA.ORCID 0009-0003-1514-5544
Douglas A BellEnvironmental Epigenomics and Disease Group, Immunity, Inflammation and Disease Laboratory, Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0001-7700-0840
Michelle R CampbellEnvironmental Epigenomics and Disease Group, Immunity, Inflammation and Disease Laboratory, Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0001-5415-6420
Suzanne N MartosEnvironmental Epigenomics and Disease Group, Immunity, Inflammation and Disease Laboratory, Intramural Research Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.ORCID 0000-0002-7693-6759
Salvatore CamioloBioSpyder, Inc., Carlsbad, California, USA.ORCID 0000-0002-8874-9993
Kevin S WhiteBioSpyder, Inc., Carlsbad, California, USA.
Nicole MartinBioSpyder, Inc., Carlsbad, California, USA.
Gioele MontisBioSpyder, Inc., Carlsbad, California, USA.
Joel McCombBioSpyder, Inc., Carlsbad, California, USA.
Bruce SeligmannBioSpyder, Inc., Carlsbad, California, USA.ORCID 0000-0002-1342-801X
Brian N ChorleyCenter for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-0676-1383

Funding

Discovery And Genetics Of Environmental Response GenesZ01ES100475 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BELL, DOUGLAS · 2002 to 2008
$2.9M
TempO-LINC high throughput high sensitivity single cell gene expression profiling assay Ph IIR44GM140771 · NIGMS · BIOSPYDER TECHNOLOGIES, INC. · PI SELIGMANN, BRUCE E. · 2023 to 2024
$2.5M
Intramural NIH HHS Z01 ES100475NIGMS NIH HHS R44 GM140771
6 · The paper itself

Abstract

We applied the TempO-LINC

Indexed as

adaptive stress responsecell statescell strate transition graphcomputational toxicologyHepaRGsingle-cell transcriptomics (SCTr)

Identifiers

PMID40766395
PMCPMC12324227

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.